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    KLF3-AS1 KLF3 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 79667, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KLF3-AS1provided by HGNC
    Official Full Name
    KLF3 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:25796
    See related
    AllianceGenome:HGNC:25796
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in ovary (RPKM 5.9), endometrium (RPKM 4.7) and 25 other tissues See more
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    Genomic context

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    See KLF3-AS1 in Genome Data Viewer
    Location:
    4p14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (38599093..38664893, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (38568181..38633994, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (38600714..38666514, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1258 Neighboring gene long intergenic non-protein coding RNA 1259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21439 Neighboring gene long intergenic non-protein coding RNA 2278 Neighboring gene KLF3-I enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:38623749-38624601 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_79844 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_79852 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_79860 Neighboring gene KLF3-II enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15359 Neighboring gene KLF3 promoter region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15362 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:38668044-38668894 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:38668895-38669744 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:38671391-38671960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:38674239-38674808 Neighboring gene KLF3-IIII enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15363 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_79886 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_79904 Neighboring gene KLF transcription factor 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21441 Neighboring gene uncharacterized LOC105374413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21442 Neighboring gene RNA, 5S ribosomal pseudogene 158

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis. Mao Q, et al. Stem Cell Res Ther, 2019 Dec 17. PMID 31847890, Free PMC Article
    2. MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis. Liu Y, et al. Cell Cycle, 2018. PMID 30324848, Free PMC Article
    3. Bone marrow mesenchymal stem cell-derived exosomes promote osteoblast proliferation, migration and inhibit apoptosis by regulating KLF3-AS1/miR-338-3p. Liu D, et al. BMC Musculoskelet Disord, 2024 Feb 9. PMID 38336637, Free PMC Article
    4. The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves the degenerative changes in human nucleus pulposus cells. Chen S, et al. Cell Tissue Res, 2023 Jul. PMID 37052702
    5. Silencing of lncRNA KLF3-AS1 represses cell growth in osteosarcoma via miR-338-3p/MEF2C axis. Chen C, et al. J Clin Lab Anal, 2022 Nov. PMID 36250223, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bone marrow mesenchymal stem cell-derived exosomes promote osteoblast proliferation, migration and inhibit apoptosis by regulating KLF3-AS1/miR-338-3p.
      Title: Bone marrow mesenchymal stem cell-derived exosomes promote osteoblast proliferation, migration and inhibit apoptosis by regulating KLF3-AS1/miR-338-3p.
    2. The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves the degenerative changes in human nucleus pulposus cells.
      Title: The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves the degenerative changes in human nucleus pulposus cells.
    3. Silencing of lncRNA KLF3-AS1 represses cell growth in osteosarcoma via miR-338-3p/MEF2C axis.
      Title: Silencing of lncRNA KLF3-AS1 represses cell growth in osteosarcoma via miR-338-3p/MEF2C axis.
    4. Overexpression of KLF3-AS1 in exosomes leads to reduced myocardial infarction area, decreased cell apoptosis and pyroptosis, and attenuated myocardial infarction progression. KLF3-AS1 can sponge miR-138-5p to regulate Sirt1 expression. miR-138-5p inhibitor transfection and KLF3-AS1 exosome incubation contribute to attenuated pyroptosis and myocardial infarction both in vivo and in vitro
      Title: LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis.
    5. Exosomal KLF3-AS1 derived from mesenchymal stem cells is involved in MSC-exosome-mediated chondrocyte proliferation induction and chondrocyte apoptosis inhibition via miR-206/GIT1 axis.
      Title: MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Clone Names

    • FLJ13197

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026804.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC021860

    2. NR_171644.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC021860

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      38599093..38664893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      38568181..38633994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024614.1: Suppressed sequence

      Description
      NM_024614.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

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