MIRLET7F2 microRNA let-7f-2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIRLET7F2provided by HGNC
Official Full Name: microRNA let-7f-2provided by HGNC
Primary source: HGNC:HGNC:31484
See related: Ensembl:ENSG00000208012 MIM:300721; miRBase:MI0000068; AllianceGenome:HGNC:31484
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LET7F2; let-7f-2; MIRNLET7F2
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: Xp11.22

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (53557192..53557274, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (52843550..52843632, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (53584153..53584235, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic polymorphisms of pri-let-7f, gene-environment and gene-gene interactions, and associations with ischemic stroke risk in Liaoning Province.
Title: Genetic polymorphisms of pri-let-7f, gene-environment and gene-gene interactions, and associations with ischemic stroke risk in Liaoning Province.
Identification of let-7f and miR-338 as plasma-based biomarkers for sporadic amyotrophic lateral sclerosis using meta-analysis and empirical validation.
Title: Identification of let-7f and miR-338 as plasma-based biomarkers for sporadic amyotrophic lateral sclerosis using meta-analysis and empirical validation.
Downregulation of microRNA let-7f mediated the Adriamycin resistance in leukemia cell line.
Title: Downregulation of microRNA let-7f mediated the Adriamycin resistance in leukemia cell line.
Hypoxia-induced let-7f-5p/TARBP2 feedback loop regulates osteosarcoma cell proliferation and invasion by inhibiting the Wnt signaling pathway.
Title: Hypoxia-induced let-7f-5p/TARBP2 feedback loop regulates osteosarcoma cell proliferation and invasion by inhibiting the Wnt signaling pathway.
let-7f-5p functions as a potential inhibitor of Th17 differentiation in the pathogenesis of multiple sclerosis by targeting STAT3
Title: Let-7f-5p suppresses Th17 differentiation via targeting STAT3 in multiple sclerosis.
genetic association study in population in Beijing, China: Data suggest SNPs in mirnlet7 (rs10993081 mirnlet7d, rs10877887 mirnlet7i, rs17276588 mirnlet7f) on chromosomes 9, 12, x are associated with metabolic syndrome in population studied.
Title: Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population.
Study show that Let-7f is down-regulated in glioma tissue and cell lines; its enhanced expression suppresses glioma cells proliferation, migration, and invasion via direct targeting perisotin suggesting it as an important role in glioma pathogenesis.
Title: Let-7f Inhibits Glioma Cell Proliferation, Migration, and Invasion by Targeting Periostin.
The combination of serum let-7b, 7d, and 7f levels during the proliferative phase may serve as a diagnostic marker for endometriosis.
Title: Circulating microRNAs as potential biomarkers for endometriosis.
miR-205 and let-7f are biomarkers for ovarian cancer and may be predictive of ovarian cancer prognosis.
Title: Plasma miRNAs as diagnostic and prognostic biomarkers for ovarian cancer.
Data show that Let-7f blocks IL-23R expression through its complementary target sequence within 3' untranslated region of target gene.
Title: IL-23 receptor regulation by Let-7f in human CD4+ memory T cells.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.