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    Tnp1 transition protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 21958, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnp1provided by MGI
    Official Full Name
    transition protein 1provided by MGI
    Primary source
    MGI:MGI:98784
    See related
    Ensembl:ENSMUSG00000026182 AllianceGenome:MGI:98784
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TP1; Tp-1; Stp-1
    Summary
    Predicted to enable DNA binding activity. Involved in positive regulation of protein processing and sperm DNA condensation. Acts upstream of or within spermatogenesis. Located in nucleus. Part of nucleosome. Is expressed in testis. Orthologous to human TNP1 (transition protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 1508.1) See more
    Orthologs
    NEW
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    Genomic context

    See Tnp1 in Genome Data Viewer
    Location:
    1 C3; 1 36.94 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (73054233..73055058, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (73015074..73015899, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01297 Neighboring gene exportin 5 pseudogene Neighboring gene predicted gene, 31137 Neighboring gene testicular germ cell expressed HSF2 interacting lncRNA Neighboring gene STARR-seq mESC enhancer starr_01299 Neighboring gene predicted gene, 53561

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heterochromatin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nucleosome disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sexual reproduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sexual reproduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in single strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in single strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sperm DNA condensation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatid nucleus elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatid nucleus elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatid nucleus elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in male germ cell nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in male germ cell nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    spermatid nuclear transition protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009407.2NP_033433.1  spermatid nuclear transition protein 1

      See identical proteins and their annotated locations for NP_033433.1

      Status: VALIDATED

      Source sequence(s)
      BC048494, BF152963
      Consensus CDS
      CCDS35611.1
      UniProtKB/Swiss-Prot
      P10856
      UniProtKB/TrEMBL
      Q545L6
      Related
      ENSMUSP00000027374.6, ENSMUST00000027374.7
      Conserved Domains (1) summary
      pfam02079
      Location:252
      TP1; Nuclear transition protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      73054233..73055058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)