Spmap2 sperm microtubule associated protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spmap2provided by MGI
Official Full Name: sperm microtubule associated protein 2provided by MGI
Primary source: MGI:MGI:1338756
See related: Ensembl:ENSMUSG00000020317 AllianceGenome:MGI:1338756
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Theg
Summary: Acts upstream of or within spermatogenesis. Predicted to be located in cytoplasm. Is expressed in large intestine; metanephros; ovary; submandibular gland; and testis. Orthologous to human SPMAP2 (sperm microtubule associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 111.0) See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79412311..79422970, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79576477..79587136, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of either the C-terminal or N-terminal regions of the Theg protein did not affect spermatogenesis or fertility in the mouse.
Title: Male mice lacking the Theg (testicular haploid expressed gene) protein undergo normal spermatogenesis and are fertile.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Transgenic (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sperm microtubule associated protein 2

Names: testicular haploid expressed gene product; testicular haploid expressed gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001428846.1 → NP_001415775.1 sperm microtubule associated protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC132265
NM_011583.4 → NP_035713.1 sperm microtubule associated protein 2 isoform 1

See identical proteins and their annotated locations for NP_035713.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC132265

Consensus CDS

CCDS23977.1

UniProtKB/Swiss-Prot

Q6P8H9, Q9JMB1, Q9QZ27

Related

ENSMUSP00000020566.7, ENSMUST00000020566.7

Conserved Domains (1) summary

pfam14912
Location:209 → 267

THEG; Testicular haploid expressed repeat
NM_199226.2 → NP_954696.1 sperm microtubule associated protein 2 isoform 2

See identical proteins and their annotated locations for NP_954696.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment in the N-terminal region, compared to isoform 1.

Source sequence(s)

AC132265

Consensus CDS

CCDS23978.1

UniProtKB/Swiss-Prot

Q9JMB1

Related

ENSMUSP00000076647.7, ENSMUST00000077433.13

Conserved Domains (1) summary

pfam14912
Location:185 → 243

THEG; Testicular haploid expressed repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

79412311..79422970 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513579.3 → XP_006513642.1 sperm microtubule associated protein 2 isoform X1

Conserved Domains (1) summary

pfam14912
Location:212 → 267

THEG; Testicular haploid expressed repeat