Slit3 slit guidance ligand 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slit3provided by MGI
Official Full Name: slit guidance ligand 3provided by MGI
Primary source: MGI:MGI:1315202
See related: Ensembl:ENSMUSG00000056427 AllianceGenome:MGI:1315202
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Slil2; Slit1; b2b2362.1Clo
Summary: Predicted to enable Roundabout binding activity and heparin binding activity. Involved in aortic valve morphogenesis; atrioventricular valve morphogenesis; and ventricular septum morphogenesis. Acts upstream of or within several processes, including axon guidance; negative regulation of cell population proliferation; and negative regulation of gene expression. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and sensory organ. Used to study congenital diaphragmatic hernia. Orthologous to human SLIT3 (slit guidance ligand 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in lung adult (RPKM 31.9), subcutaneous fat pad adult (RPKM 28.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A4; 11 20.29 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (35012283..35599334)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (35121456..35708507)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy.
Title: Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy.
SLIT3-mediated fibroblast signaling: a promising target for antifibrotic therapies.
Title: SLIT3-mediated fibroblast signaling: a promising target for antifibrotic therapies.
Concomitant induction of SLIT3 and microRNA-218-2 in macrophages by toll-like receptor 4 activation limits osteoclast commitment.
Title: Concomitant induction of SLIT3 and microRNA-218-2 in macrophages by toll-like receptor 4 activation limits osteoclast commitment.
SLIT3 promotes myogenic differentiation as a novel therapeutic factor against muscle loss.
Title: SLIT3 promotes myogenic differentiation as a novel therapeutic factor against muscle loss.
Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue.
Title: Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue.
Tissue-specific angiogenic and invasive properties of human neonatal thymus and bone MSCs: Role of SLIT3-ROBO1.
Title: Tissue-specific angiogenic and invasive properties of human neonatal thymus and bone MSCs: Role of SLIT3-ROBO1.
SLIT3 deficiency attenuates pressure overload-induced cardiac fibrosis and remodeling.
Title: SLIT3 deficiency attenuates pressure overload-induced cardiac fibrosis and remodeling.
these results indicate that SLIT3 plays an osteoprotective role by synchronously stimulating bone formation and inhibiting bone resorption, making it a potential therapeutic target for metabolic bone diseases.
Title: Osteoclast-secreted SLIT3 coordinates bone resorption and formation.
these indicate that SLIT3/ROBO2 promotes chondrocyte maturation via the inhibition of beta-catenin signaling.
Title: SLIT3 regulates endochondral ossification by β-catenin suppression in chondrocytes.
A small truncated recombinant SLIT3 protein increased bone mass in an osteopenic mouse model.
Title: Osteoclast-derived SLIT3 is a coupling factor linking bone resorption to bone formation.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (6)
Gene trapped (1) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236552

BE197067 (e-PCR)
- UniSTS:208654

C87259 (e-PCR)
- UniSTS:208655

Slit3 (e-PCR), detects polymorphism
- UniSTS:463431

Slit3 (e-PCR), detects polymorphism
- UniSTS:463432

Slit3 (e-PCR), detects polymorphism
- UniSTS:463433

D11Dcr6 (e-PCR), detects polymorphism
- UniSTS:507479

NoName (e-PCR)
- UniSTS:224405

MT3692 (e-PCR)
- UniSTS:116384

D11Mit186 (e-PCR), detects polymorphism
- UniSTS:126382

AU048637 (e-PCR)
- UniSTS:145087

Slit3 (e-PCR), detects polymorphism
- UniSTS:527554

D11Mit231.2 (e-PCR), detects polymorphism
- UniSTS:126432

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Roundabout binding	IBA Inferred from Biological aspect of Ancestor more info
enables Roundabout binding	IEA Inferred from Electronic Annotation more info
enables Roundabout binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Roundabout signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Roundabout signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aortic valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process involved in luteolysis	IEA Inferred from Electronic Annotation more info
involved_in atrioventricular valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in axon extension involved in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to cortisol	IEA Inferred from Electronic Annotation more info
involved_in ventricular septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: slit homolog 3 protein

Names: slit-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011412.3 → NP_035542.2 slit homolog 3 protein precursor

See identical proteins and their annotated locations for NP_035542.2

Status: VALIDATED

Source sequence(s)

AF088902, AK147292, BB645429, BC150780

Consensus CDS

CCDS24542.1

UniProtKB/Swiss-Prot

B1ATW4, Q9WVB4

UniProtKB/TrEMBL

B2RX06

Related

ENSMUSP00000066857.4, ENSMUST00000069837.4

Conserved Domains (12) summary

smart00013
Location:725 → 756

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:857 → 906

LRRCT; Leucine rich repeat C-terminal domain

cd00054
Location:1076 → 1110

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00116
Location:49 → 220

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:64 → 86

LRR_RI; leucine-rich repeat [structural motif]

pfam00008
Location:1123 → 1153

EGF; EGF-like domain

pfam01462
Location:33 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam02210
Location:1188 → 1314

Laminin_G_2; Laminin G domain

pfam12799
Location:331 → 371

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:775 → 835

LRR_8; Leucine rich repeat

cl15307
Location:437 → 467

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cl21545
Location:1463 → 1519

GHB_like; Glycoprotein hormone beta chain homologues