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    Ube2b ubiquitin-conjugating enzyme E2B [ Mus musculus (house mouse) ]

    Gene ID: 22210, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ube2bprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Bprovided by MGI
    Primary source
    MGI:MGI:102944
    See related
    Ensembl:ENSMUSG00000020390 AllianceGenome:MGI:102944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HR6B; E214K; Rad6b; mHR6B; E2-14k
    Summary
    Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including chromosome organization; positive regulation of reciprocal meiotic recombination; and sperm axoneme assembly. Located in XY body and chromatin. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human UBE2B (ubiquitin conjugating enzyme E2 B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 40.4), heart adult (RPKM 37.3) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ube2b in Genome Data Viewer
    Location:
    11 B1.3; 11 31.82 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51875965..51894972, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51985138..52004145, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CDKN2A interacting protein N-terminal like Neighboring gene predicted gene, 26061 Neighboring gene STARR-seq mESC enhancer starr_29438 Neighboring gene cyclin dependent kinase like 3 Neighboring gene STARR-seq mESC enhancer starr_29439 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:51879429-51879612 Neighboring gene STARR-positive B cell enhancer ABC_E8875 Neighboring gene STARR-positive B cell enhancer ABC_E10674 Neighboring gene protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Neighboring gene predicted gene, 30631 Neighboring gene microRNA 3061

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chiasma assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of ectopic germ cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within leptotene IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within meiotic telomere clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of developmental process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of post-translational protein modification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postreplication repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in postreplication repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autoubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to UV IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within synaptonemal complex organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of HULC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of HULC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of HULC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in XY body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in replication fork IEA
    Inferred from Electronic Annotation
    more info
     
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 B
    Names
    E2 ubiquitin-conjugating enzyme B
    RAD6 homolog B
    ubiquitin carrier protein B
    ubiquitin-conjugating enzyme E2B, RAD6 homology
    ubiquitin-protein ligase B
    NP_001349614.1
    NP_001349615.1
    NP_033484.3
    XP_011247269.1
    XP_030101785.1
    XP_030101786.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362685.1NP_001349614.1  ubiquitin-conjugating enzyme E2 B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL669920, CF951907
      Consensus CDS
      CCDS24664.1
      UniProtKB/Swiss-Prot
      P63147, Q3UGS2
      UniProtKB/TrEMBL
      A2RSE4, Q3TUV9
      Related
      ENSMUSP00000104714.2, ENSMUST00000109086.8
      Conserved Domains (1) summary
      pfam00179
      Location:8145
      UQ_con; Ubiquitin-conjugating enzyme
    2. NM_001362686.1NP_001349615.1  ubiquitin-conjugating enzyme E2 B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669920
      Conserved Domains (1) summary
      pfam00179
      Location:8115
      UQ_con; Ubiquitin-conjugating enzyme
    3. NM_009458.5NP_033484.3  ubiquitin-conjugating enzyme E2 B isoform 1

      See identical proteins and their annotated locations for NP_033484.3

      Status: VALIDATED

      Source sequence(s)
      AK147785, AK169229, AL669920, BE944184
      Consensus CDS
      CCDS24664.1
      UniProtKB/Swiss-Prot
      P63147, Q3UGS2
      UniProtKB/TrEMBL
      A2RSE4, Q3TUV9
      Related
      ENSMUSP00000020657.7, ENSMUST00000020657.13
      Conserved Domains (1) summary
      pfam00179
      Location:8145
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      51875965..51894972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245925.1XP_030101785.1  ubiquitin-conjugating enzyme E2 B isoform X1

      UniProtKB/Swiss-Prot
      P63147, Q3UGS2
      UniProtKB/TrEMBL
      A2RSE4, Q3TUV9
      Conserved Domains (1) summary
      pfam00179
      Location:8145
      UQ_con; Ubiquitin-conjugating enzyme
    2. XM_011248967.2XP_011247269.1  ubiquitin-conjugating enzyme E2 B isoform X1

      See identical proteins and their annotated locations for XP_011247269.1

      UniProtKB/Swiss-Prot
      P63147, Q3UGS2
      UniProtKB/TrEMBL
      A2RSE4, Q3TUV9
      Conserved Domains (1) summary
      pfam00179
      Location:8145
      UQ_con; Ubiquitin-conjugating enzyme
    3. XM_030245926.1XP_030101786.1  ubiquitin-conjugating enzyme E2 B isoform X2

      Conserved Domains (1) summary
      pfam00179
      Location:8115
      UQ_con; Ubiquitin-conjugating enzyme