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    Lyrm7 LYR motif containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 75530, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lyrm7provided by MGI
    Official Full Name
    LYR motif containing 7provided by MGI
    Primary source
    MGI:MGI:1922780
    See related
    Ensembl:ENSMUSG00000020268 AllianceGenome:MGI:1922780
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700024C24Rik; 9330147L21Rik
    Summary
    Predicted to enable protein folding chaperone. Predicted to be involved in cellular respiration and mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 8. Orthologous to human LYRM7 (LYR motif containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 4.6), cortex adult (RPKM 2.1) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lyrm7 in Genome Data Viewer
    Location:
    11 B1.3; 11 32.13 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54717692..54751738, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54826866..54860921, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CDC42 small effector 2 Neighboring gene STARR-seq mESC enhancer starr_29510 Neighboring gene predicted gene 12227 Neighboring gene STARR-positive B cell enhancer ABC_E8404 Neighboring gene STARR-positive B cell enhancer ABC_E11480 Neighboring gene STARR-positive B cell enhancer ABC_E6985 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:54615437-54615636 Neighboring gene STARR-positive B cell enhancer ABC_E2988 Neighboring gene LYR motif containing 7, opposite strand Neighboring gene STARR-seq mESC enhancer starr_29513 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:54663563-54663764 Neighboring gene ATPase family, AAA domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29515 Neighboring gene predicted gene, 31490 Neighboring gene VISTA enhancer mm1343 Neighboring gene histidine triad nucleotide binding protein 1 Neighboring gene glutathione peroxidase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    2. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    complex III assembly factor LYRM7
    Names
    LYR motif-containing protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363191.2 → NP_001350120.2  complex III assembly factor LYRM7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL954817
      Conserved Domains (1) summary
      pfam05347
      Location:5 → 58
      Complex1_LYR; Complex 1 protein (LYR family)

    2. NM_029327.5 → NP_083603.4  complex III assembly factor LYRM7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL954817
      Consensus CDS
      CCDS36154.2
      UniProtKB/Swiss-Prot
      B7ZDF8, Q9DA03
      Related
      ENSMUSP00000120778.2, ENSMUST00000144164.9
      Conserved Domains (1) summary
      pfam05347
      Location:5 → 59
      Complex1_LYR; Complex 1 protein (LYR family)

    RNA

    1. NR_156460.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL954817

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      54717692..54751738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314815.3 → XP_017170304.1  complex III assembly factor LYRM7 isoform X1

      Conserved Domains (1) summary
      cd20267
      Location:36 → 83
      Complex1_LYR_LYRM7; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins

    RNA

    1. XR_388549.2 RNA Sequence

    2. XR_388548.2 RNA Sequence

    3. XR_003949526.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DA03.2 GenPept UniProtKB/Swiss-Prot:Q9DA03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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