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    Ndrg2 N-myc downstream regulated gene 2 [ Mus musculus (house mouse) ]

    Gene ID: 29811, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ndrg2provided by MGI
    Official Full Name
    N-myc downstream regulated gene 2provided by MGI
    Primary source
    MGI:MGI:1352498
    See related
    Ensembl:ENSMUSG00000004558 AllianceGenome:MGI:1352498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ndr2; SYLD
    Summary
    Acts upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of vascular associated smooth muscle cell proliferation; and regulation of cytokine production. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculoskeletal system; and sensory organ. Orthologous to human NDRG2 (NDRG family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 416.8), heart adult (RPKM 317.4) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ndrg2 in Genome Data Viewer
    Location:
    14 C2; 14 26.72 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52142738..52151463, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51905271..51914004, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 17 Neighboring gene solute carrier family 39 (zinc transporter), member 2 Neighboring gene tubulin polymerization-promoting protein family member 2 Neighboring gene ribonuclease, RNase A family, 13 (non-active)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein NDRG2
    Names
    N-myc downstream regulated 2
    N-myc downstream-regulated gene 2 protein
    protein Ndr2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145959.2NP_001139431.1  protein NDRG2 isoform 2

      See identical proteins and their annotated locations for NP_001139431.1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS49486.1
      UniProtKB/Swiss-Prot
      Q9QYG0
      Related
      ENSMUSP00000107259.4, ENSMUST00000111632.5
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family
    2. NM_001360264.2NP_001347193.1  protein NDRG2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Conserved Domains (1) summary
      pfam03096
      Location:43321
      Ndr; Ndr family
    3. NM_001360265.2NP_001347194.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS27047.1
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    4. NM_001360266.2NP_001347195.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS27047.1
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    5. NM_001360267.2NP_001347196.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS27047.1
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    6. NM_001360268.2NP_001347197.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS27047.1
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    7. NM_001360269.2NP_001347198.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS27047.1
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    8. NM_001360270.2NP_001347199.1  protein NDRG2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Conserved Domains (1) summary
      pfam03096
      Location:29307
      Ndr; Ndr family
    9. NM_001360271.2NP_001347200.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS49486.1
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family
    10. NM_001360272.2NP_001347201.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS49486.1
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family
    11. NM_001360273.2NP_001347202.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS49486.1
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family
    12. NM_001360274.2NP_001347203.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS49486.1
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family
    13. NM_001360276.2NP_001347205.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS49486.1
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family
    14. NM_001424691.1NP_001411620.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087
    15. NM_001424692.1NP_001411621.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087
    16. NM_001424693.1NP_001411622.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087
    17. NM_001424694.1NP_001411623.1  protein NDRG2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125087
    18. NM_001424695.1NP_001411624.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    19. NM_001424696.1NP_001411625.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    20. NM_001424697.1NP_001411626.1  protein NDRG2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
    21. NM_001424698.1NP_001411627.1  protein NDRG2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC125087
    22. NM_001424699.1NP_001411628.1  protein NDRG2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC125087
    23. NM_001424700.1NP_001411629.1  protein NDRG2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC125087
    24. NM_001424701.1NP_001411630.1  protein NDRG2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC125087
    25. NM_013864.3NP_038892.1  protein NDRG2 isoform 1

      See identical proteins and their annotated locations for NP_038892.1

      Status: VALIDATED

      Source sequence(s)
      AC125087
      Consensus CDS
      CCDS27047.1
      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
      Related
      ENSMUSP00000004673.8, ENSMUST00000004673.15
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      52142738..52151463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158660.1XP_036014553.1  protein NDRG2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TI48, Q3TY42, Q3U3T5, Q69ZN2, Q8C661, Q9QYG0
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    2. XM_036158662.1XP_036014555.1  protein NDRG2 isoform X2

      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family