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    Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 110115, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cyp11b1provided by MGI
    Official Full Name
    cytochrome P450, family 11, subfamily b, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:88583
    See related
    Ensembl:ENSMUSG00000075604 AllianceGenome:MGI:88583
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FHI; CPN1; Cyp11b; Cyp11b-1
    Summary
    Enables corticosterone 18-monooxygenase activity. Acts upstream of or within glucocorticoid biosynthetic process. Located in mitochondrion. Is expressed in adrenal gland; gland; lung; and testis. Used to study congenital adrenal hyperplasia. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (cytochrome P450 family 11 subfamily B member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward adrenal adult (RPKM 843.1) See more
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    Genomic context

    See Cyp11b1 in Genome Data Viewer
    Location:
    15 D3; 15 34.29 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (74706741..74713492, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (74834892..74841643, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member K Neighboring gene glycosylphosphatidylinositol anchored molecule like Neighboring gene STARR-seq mESC enhancer starr_38997 Neighboring gene glycosylphosphatidylinositol anchored molecule like 2 Neighboring gene Cyp11b2 promoter Neighboring gene cytochrome P450, family 11, subfamily b, polypeptide 2 Neighboring gene predicted gene, 41347 Neighboring gene STARR-seq mESC enhancer starr_38998 Neighboring gene lymphocyte antigen 6 family member M

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables corticosterone 18-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables corticosterone 18-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid 11-beta-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables steroid 11-beta-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in aldosterone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in aldosterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to peptide hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cortisol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cortisol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glucocorticoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within glucocorticoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within glucocorticoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucocorticoid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytochrome P450, family 11, subfamily b, polypeptide 1
    Names
    steroid-11-beta-hydroxylase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033229.4NP_001028401.3  cytochrome P450, family 11, subfamily b, polypeptide 1

      Status: VALIDATED

      Source sequence(s)
      AC139671
      Consensus CDS
      CCDS27535.1
      Related
      ENSMUSP00000127888.2, ENSMUST00000170259.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      74706741..74713492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)