Cldn5 claudin 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cldn5provided by MGI
Official Full Name: claudin 5provided by MGI
Primary source: MGI:MGI:1276112
See related: Ensembl:ENSMUSG00000041378 AllianceGenome:MGI:1276112
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MBEC1; Tmvcf
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a critical component of endothelial tight junctions that control pericellular permeability. The knockout mice lacking this gene died within 10 h of birth and the blood-brain barrier in these mice against small molecules was selectively affected. This gene is expressed strongly in endothelium of normal lung and plays a regulation role during acrolein-induced acute lung injury. [provided by RefSeq, Aug 2010]
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 11.63 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (18595597..18597012)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (18776847..18778262)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Cldn5 -and increase in Irf7-in the hippocampus and cerebral cortex of diabetic mice at the early symptomatic stage.
Title: Loss of Cldn5 -and increase in Irf7-in the hippocampus and cerebral cortex of diabetic mice at the early symptomatic stage.
A novel function of claudin-5 in maintaining the structural integrity of the heart and its implications in cardiac pathology.
Title: A novel function of claudin-5 in maintaining the structural integrity of the heart and its implications in cardiac pathology.
Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage.
Title: Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage.
Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava.
Title: Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava.
Blood-brain barrier dysfunction mediated by the EZH2-Claudin-5 axis drives stress-induced TNF-alpha infiltration and depression-like behaviors.
Title: Blood-brain barrier dysfunction mediated by the EZH2-Claudin-5 axis drives stress-induced TNF-α infiltration and depression-like behaviors.
Ultrasound-guided transfection of claudin-5 improves lung endothelial barrier function in lung injury without impairing innate immunity.
Title: Ultrasound-guided transfection of claudin-5 improves lung endothelial barrier function in lung injury without impairing innate immunity.
The CLDN5 gene at the blood-brain barrier in health and disease.
Title: The CLDN5 gene at the blood-brain barrier in health and disease.
Cardiac-specific overexpression of Claudin-5 exerts protection against myocardial ischemia and reperfusion injury.
Title: Cardiac-specific overexpression of Claudin-5 exerts protection against myocardial ischemia and reperfusion injury.
Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner.
Title: Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner.
Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis.
Title: Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (5) 1 citation

General gene information

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Markers

AF035814 (e-PCR)
- UniSTS:160537

Cldn5 (e-PCR), detects polymorphism
- UniSTS:265696

UniSTS:465379 (e-PCR)
- UniSTS:465379

Cldn5 (e-PCR), detects polymorphism
- UniSTS:465379

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion	IC Inferred by Curator more info	PubMed
involved_in cell-cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in establishment of blood-retinal barrier	IEA Inferred from Electronic Annotation more info
involved_in establishment of blood-retinal barrier	ISO Inferred from Sequence Orthology more info
involved_in maintenance of blood-brain barrier	IEA Inferred from Electronic Annotation more info
involved_in maintenance of blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in myelination	IEA Inferred from Electronic Annotation more info
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular permeability	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of establishment of endothelial barrier	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Schmidt-Lanterman incisure	IEA Inferred from Electronic Annotation more info
located_in Schmidt-Lanterman incisure	ISO Inferred from Sequence Orthology more info
located_in apicolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	IEA Inferred from Electronic Annotation more info
colocalizes_with cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in paranode region of axon	IEA Inferred from Electronic Annotation more info
located_in paranode region of axon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: claudin-5

Names: brain endothelial cell clone 1 protein; lung-specific membrane protein; transmembrane protein deleted in VCFS

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.