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    Adgrf5 adhesion G protein-coupled receptor F5 [ Mus musculus (house mouse) ]

    Gene ID: 224792, updated on 7-Dec-2024

    Summary

    Official Symbol
    Adgrf5provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor F5provided by MGI
    Primary source
    MGI:MGI:2182928
    See related
    Ensembl:ENSMUSG00000056492 AllianceGenome:MGI:2182928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpr116; mKIAA0758; 9330185D23; 8430401C09Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Involved in surfactant homeostasis. Acts upstream of or within several processes, including glomerular filtration; negative regulation of macrophage activation; and pharyngeal arch artery morphogenesis. Located in apical part of cell. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human ADGRF5 (adhesion G protein-coupled receptor F5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung adult (RPKM 73.9), subcutaneous fat pad adult (RPKM 17.7) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adgrf5 in Genome Data Viewer
    Location:
    17 B3; 17 19.73 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (43671225..43770448)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (43360329..43459557)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54007 Neighboring gene STARR-positive B cell enhancer mm9_chr17:43402088-43402388 Neighboring gene adhesion G protein-coupled receptor F1 Neighboring gene STARR-seq mESC enhancer starr_42590 Neighboring gene predicted gene, 25135 Neighboring gene STARR-seq mESC enhancer starr_42593 Neighboring gene STARR-seq mESC enhancer starr_42594 Neighboring gene meprin 1 alpha Neighboring gene ankyrin repeat domain 66

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in energy reserve metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within energy reserve metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glomerular filtration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within pharyngeal arch artery morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within surfactant homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in surfactant homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor F5
    Names
    G protein coupled receptor Gpr116
    G protein-coupled receptor 116
    G-protein coupled hepta-helical receptor Ig-hepta
    Ig-Hepta
    probable G-protein coupled receptor 116

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081178.2NP_001074647.1  adhesion G protein-coupled receptor F5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001074647.1

      Status: VALIDATED

      Source sequence(s)
      AC169504, CT010585, CT025700
      Consensus CDS
      CCDS37622.1
      UniProtKB/Swiss-Prot
      G5E8Q8
      UniProtKB/TrEMBL
      A0A286YDT5
      Related
      ENSMUSP00000109229.2, ENSMUST00000113599.2
      Conserved Domains (5) summary
      smart00409
      Location:283357
      IG; Immunoglobulin
      pfam01825
      Location:951998
      GPS; GPCR proteolysis site, GPS, motif
      pfam13927
      Location:471544
      Ig_3; Immunoglobulin domain
      cd14964
      Location:10131038
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10121285
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. NM_001357332.1NP_001344261.1  adhesion G protein-coupled receptor F5 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169504, AW457181, CT010585, CT025700
      UniProtKB/TrEMBL
      A0A286YDT5
      Conserved Domains (5) summary
      smart00410
      Location:301375
      IG_like; Immunoglobulin like
      cd14964
      Location:10321056
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam00047
      Location:495568
      ig; Immunoglobulin domain
      pfam01825
      Location:9691016
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:10301303
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. NM_001404529.1NP_001391458.1  adhesion G protein-coupled receptor F5 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169504, CT010585, CT025700
      UniProtKB/TrEMBL
      A0A286YDT5
    4. NM_001404530.1NP_001391459.1  adhesion G protein-coupled receptor F5 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169504, CT010585, CT025700
      UniProtKB/TrEMBL
      A0A286YDT5
    5. NM_001404536.1NP_001391465.1  adhesion G protein-coupled receptor F5 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169504, CT010585, CT025700
    6. NM_001404541.1NP_001391470.1  adhesion G protein-coupled receptor F5 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169504, CT010585, CT025700
      UniProtKB/TrEMBL
      A0A286YDT5
    7. NM_001404546.1NP_001391475.1  adhesion G protein-coupled receptor F5 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169504, CT010585, CT025700
      UniProtKB/TrEMBL
      A0A286YDT5
    8. NM_001404548.1NP_001391477.1  adhesion G protein-coupled receptor F5 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC169504, CT010585, CT025700
      UniProtKB/TrEMBL
      A0A286YDT5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      43671225..43770448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524128.5XP_006524191.1  adhesion G protein-coupled receptor F5 isoform X3

      See identical proteins and their annotated locations for XP_006524191.1

      UniProtKB/TrEMBL
      A0A286YDT5
      Related
      ENSMUSP00000153373.2, ENSMUST00000225962.2
      Conserved Domains (5) summary
      smart00409
      Location:283357
      IG; Immunoglobulin
      cd14964
      Location:10531078
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam00047
      Location:517590
      ig; Immunoglobulin domain
      pfam01825
      Location:9911038
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:10521325
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_036160548.1XP_036016441.1  adhesion G protein-coupled receptor F5 isoform X7

      UniProtKB/Swiss-Prot
      G5E8Q8
      UniProtKB/TrEMBL
      A0A286YDT5
      Related
      ENSMUSP00000153049.2, ENSMUST00000226087.2
      Conserved Domains (5) summary
      smart00409
      Location:283357
      IG; Immunoglobulin
      pfam01825
      Location:951998
      GPS; GPCR proteolysis site, GPS, motif
      pfam13927
      Location:471544
      Ig_3; Immunoglobulin domain
      cd14964
      Location:10131038
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10121285
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. XM_036160547.1XP_036016440.1  adhesion G protein-coupled receptor F5 isoform X6

      Conserved Domains (5) summary
      smart00409
      Location:301375
      IG; Immunoglobulin
      pfam00047
      Location:491568
      ig; Immunoglobulin domain
      pfam01825
      Location:9691016
      GPS; GPCR proteolysis site, GPS, motif
      cd14964
      Location:10311056
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10301303
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    4. XM_036160550.1XP_036016443.1  adhesion G protein-coupled receptor F5 isoform X8

      Conserved Domains (5) summary
      smart00409
      Location:283357
      IG; Immunoglobulin
      pfam00047
      Location:473550
      ig; Immunoglobulin domain
      pfam01825
      Location:951998
      GPS; GPCR proteolysis site, GPS, motif
      cd14964
      Location:10131038
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10121285
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    5. XM_036160549.1XP_036016442.1  adhesion G protein-coupled receptor F5 isoform X8

      Conserved Domains (5) summary
      smart00409
      Location:283357
      IG; Immunoglobulin
      pfam00047
      Location:473550
      ig; Immunoglobulin domain
      pfam01825
      Location:951998
      GPS; GPCR proteolysis site, GPS, motif
      cd14964
      Location:10131038
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:10121285
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily