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    Sulf2 sulfatase 2 [ Mus musculus (house mouse) ]

    Gene ID: 72043, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sulf2provided by MGI
    Official Full Name
    sulfatase 2provided by MGI
    Primary source
    MGI:MGI:1919293
    See related
    Ensembl:ENSMUSG00000006800 AllianceGenome:MGI:1919293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MSulf-2; mKIAA1247; 2010004N24Rik
    Summary
    Enables N-acetylglucosamine-6-sulfatase activity. Involved in several processes, including esophagus smooth muscle contraction; glomerular filtration; and skeletal system development. Acts upstream of or within several processes, including liver regeneration; positive regulation of canonical Wnt signaling pathway; and regulation of hepatocyte proliferation. Located in plasma membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; limb; and sensory organ. Orthologous to human SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 145.3), limb E14.5 (RPKM 91.2) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sulf2 in Genome Data Viewer
    Location:
    2 H3; 2 86.31 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165915819..165997603, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (166073899..166155683, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06372 Neighboring gene STARR-seq mESC enhancer starr_06373 Neighboring gene pluripotency associated transcript 29 Neighboring gene STARR-seq mESC enhancer starr_06376 Neighboring gene STARR-positive B cell enhancer mm9_chr2:165837827-165838127 Neighboring gene nuclear receptor coactivator 3 Neighboring gene VISTA enhancer mm1346 Neighboring gene predicted gene, 52534 Neighboring gene STARR-seq mESC enhancer starr_06387 Neighboring gene predicted gene, 30320 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:166010050-166010233 Neighboring gene STARR-seq mESC enhancer starr_06391 Neighboring gene predicted gene, 30536

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylglucosamine-6-sulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables N-acetylglucosamine-6-sulfatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables N-acetylglucosamine-6-sulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables arylsulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables arylsulfatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables glycosaminoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in bone development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chondrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in esophagus smooth muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in glial cell-derived neurotrophic factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glomerular basement membrane development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glomerular basement membrane development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in glomerular filtration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in heparan sulfate proteoglycan metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heparan sulfate proteoglycan metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heparan sulfate proteoglycan metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innervation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in kidney development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within liver regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelin production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelin production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular endothelial growth factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of vascular endothelial growth factor production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of hepatocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sulfur compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    extracellular sulfatase Sulf-2
    Names
    N-acetylglucosamine-6-sulfatase
    arylsulfatase
    NP_001239507.1
    NP_001239508.1
    NP_001342548.1
    NP_082348.2
    XP_006500272.1
    XP_006500274.1
    XP_030107960.1
    XP_030107961.1
    XP_036018478.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252578.1NP_001239507.1  extracellular sulfatase Sulf-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001239507.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 4 all encode the same isoform (1).
      Source sequence(s)
      AL589873
      Consensus CDS
      CCDS17086.1
      UniProtKB/Swiss-Prot
      B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
      UniProtKB/TrEMBL
      Q6ZPV3
      Related
      ENSMUSP00000085405.4, ENSMUST00000088086.4
      Conserved Domains (3) summary
      cd16147
      Location:43385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533666
      DUF3740; Sulfatase protein
      cl23718
      Location:754803
      ALP_like; alkaline phosphatases and sulfatases
    2. NM_001252579.1NP_001239508.1  extracellular sulfatase Sulf-2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate upstream start codon compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK034712, AL589873, CF736722
      UniProtKB/TrEMBL
      Q6ZPV3
      Conserved Domains (4) summary
      COG3119
      Location:76420
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      pfam12548
      Location:573699
      DUF3740; Sulfatase protein
      cd16147
      Location:76418
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      cl23718
      Location:787836
      ALP_like; alkaline phosphatases and sulfatases
    3. NM_001355619.1NP_001342548.1  extracellular sulfatase Sulf-2 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (1).
      Source sequence(s)
      AL589873
      Consensus CDS
      CCDS17086.1
      UniProtKB/Swiss-Prot
      B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
      UniProtKB/TrEMBL
      Q6ZPV3
      Conserved Domains (3) summary
      cd16147
      Location:43385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533666
      DUF3740; Sulfatase protein
      cl23718
      Location:754803
      ALP_like; alkaline phosphatases and sulfatases
    4. NM_028072.5NP_082348.2  extracellular sulfatase Sulf-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_082348.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (1).
      Source sequence(s)
      AK036685, AL589873, CF736722
      Consensus CDS
      CCDS17086.1
      UniProtKB/Swiss-Prot
      B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
      UniProtKB/TrEMBL
      Q6ZPV3
      Related
      ENSMUSP00000104872.3, ENSMUST00000109249.9
      Conserved Domains (3) summary
      cd16147
      Location:43385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533666
      DUF3740; Sulfatase protein
      cl23718
      Location:754803
      ALP_like; alkaline phosphatases and sulfatases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      165915819..165997603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500209.5XP_006500272.1  extracellular sulfatase Sulf-2 isoform X1

      See identical proteins and their annotated locations for XP_006500272.1

      UniProtKB/Swiss-Prot
      B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
      UniProtKB/TrEMBL
      Q6ZPV3
      Conserved Domains (3) summary
      cd16147
      Location:43385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533666
      DUF3740; Sulfatase protein
      cl23718
      Location:754803
      ALP_like; alkaline phosphatases and sulfatases
    2. XM_006500211.4XP_006500274.1  extracellular sulfatase Sulf-2 isoform X1

      See identical proteins and their annotated locations for XP_006500274.1

      UniProtKB/Swiss-Prot
      B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
      UniProtKB/TrEMBL
      Q6ZPV3
      Conserved Domains (3) summary
      cd16147
      Location:43385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533666
      DUF3740; Sulfatase protein
      cl23718
      Location:754803
      ALP_like; alkaline phosphatases and sulfatases
    3. XM_030252100.1XP_030107960.1  extracellular sulfatase Sulf-2 isoform X1

      UniProtKB/Swiss-Prot
      B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
      UniProtKB/TrEMBL
      Q6ZPV3
      Conserved Domains (3) summary
      cd16147
      Location:43385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533666
      DUF3740; Sulfatase protein
      cl23718
      Location:754803
      ALP_like; alkaline phosphatases and sulfatases
    4. XM_036162585.1XP_036018478.1  extracellular sulfatase Sulf-2 isoform X1

      UniProtKB/Swiss-Prot
      B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
      UniProtKB/TrEMBL
      Q6ZPV3
      Conserved Domains (3) summary
      cd16147
      Location:43385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533666
      DUF3740; Sulfatase protein
      cl23718
      Location:754803
      ALP_like; alkaline phosphatases and sulfatases
    5. XM_030252101.1XP_030107961.1  extracellular sulfatase Sulf-2 isoform X1

      UniProtKB/Swiss-Prot
      B2RUD5, Q3TNM3, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q8CFG0, Q9D8E2
      UniProtKB/TrEMBL
      Q6ZPV3
      Conserved Domains (3) summary
      cd16147
      Location:43385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:533666
      DUF3740; Sulfatase protein
      cl23718
      Location:754803
      ALP_like; alkaline phosphatases and sulfatases