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    Tmod4 tropomodulin 4 [ Mus musculus (house mouse) ]

    Gene ID: 50874, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmod4provided by MGI
    Official Full Name
    tropomodulin 4provided by MGI
    Primary source
    MGI:MGI:1355285
    See related
    Ensembl:ENSMUSG00000005628 AllianceGenome:MGI:1355285
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MTMOD; Sk-Tmod
    Summary
    Enables tropomyosin binding activity. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Located in striated muscle thin filament. Is expressed in diaphragm; liver; lung; and vertebral axis musculature. Orthologous to human TMOD4 (tropomodulin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 7.1), heart adult (RPKM 2.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tmod4 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95030110..95036520)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95122799..95129209)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha Neighboring gene STARR-seq mESC enhancer starr_08366 Neighboring gene predicted gene, 40095 Neighboring gene predicted gene, 22301 Neighboring gene STARR-seq mESC enhancer starr_08367 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94914795-94915038 Neighboring gene vacuolar protein sorting 72 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94937828-94938011 Neighboring gene sodium channel modifier 1 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 1 Neighboring gene microRNA 8099-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tropomyosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tropomyosin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pointed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in striated muscle thin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in striated muscle thin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in striated muscle thin filament ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tropomodulin-4
    Names
    skeletal muscle tropomodulin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428789.1NP_001415718.1  tropomodulin-4

      Status: VALIDATED

      Source sequence(s)
      AC131769
      UniProtKB/Swiss-Prot
      Q9JLH8
      UniProtKB/TrEMBL
      Q3UN19
    2. NM_001428790.1NP_001415719.1  tropomodulin-4

      Status: VALIDATED

      Source sequence(s)
      AC131769
      UniProtKB/Swiss-Prot
      Q9JLH8
      UniProtKB/TrEMBL
      Q3UN19
    3. NM_016712.5NP_057921.1  tropomodulin-4

      See identical proteins and their annotated locations for NP_057921.1

      Status: VALIDATED

      Source sequence(s)
      AC131769
      Consensus CDS
      CCDS17601.1
      UniProtKB/Swiss-Prot
      Q9JLH8
      UniProtKB/TrEMBL
      Q3UN19
      Related
      ENSMUSP00000005769.7, ENSMUST00000005769.13
      Conserved Domains (2) summary
      pfam03250
      Location:4143
      Tropomodulin
      cl39015
      Location:184286
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95030110..95036520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319636.1XP_017175125.1  tropomodulin-4 isoform X1

      UniProtKB/Swiss-Prot
      Q9JLH8
      UniProtKB/TrEMBL
      Q3UN19
      Conserved Domains (2) summary
      pfam03250
      Location:4143
      Tropomodulin
      cl39015
      Location:184286
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. XM_030252671.2XP_030108531.1  tropomodulin-4 isoform X1

      UniProtKB/Swiss-Prot
      Q9JLH8
      UniProtKB/TrEMBL
      Q3UN19
      Conserved Domains (2) summary
      pfam03250
      Location:4143
      Tropomodulin
      cl39015
      Location:184286
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. XM_030252672.2XP_030108532.1  tropomodulin-4 isoform X1

      Conserved Domains (2) summary
      pfam03250
      Location:4143
      Tropomodulin
      cl39015
      Location:184286
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    4. XM_030252670.2XP_030108530.1  tropomodulin-4 isoform X1

      Related
      ENSMUSP00000102846.2, ENSMUST00000107227.4
      Conserved Domains (2) summary
      pfam03250
      Location:4143
      Tropomodulin
      cl39015
      Location:184286
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...