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    Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) [ Mus musculus (house mouse) ]

    Gene ID: 18780, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pla2g2aprovided by MGI
    Official Full Name
    phospholipase A2, group IIA (platelets, synovial fluid)provided by MGI
    Primary source
    MGI:MGI:104642
    See related
    Ensembl:ENSMUSG00000058908 AllianceGenome:MGI:104642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EF; Mom1; Pla2; sPLA2; sPla2-IIA
    Summary
    Proteins belonging to the phospholipase A2 (PLA2) family hydrolyze phospholipids into sn2 fatty acids and lysophospholipids. They function in a variety of cellular processes, including the digestion of phospholipids and the production of molecules that induce inflammatory responses. This gene encodes a member of the group II class of secretory PLA2s. The secreted enzyme binds to heparin on the cell surface. Mutations in this gene increase the occurrence of intestinal polyps caused by a dominant mutation in the adenomatosis polyposis coli gene. A frameshift inactivates this gene product in some mouse strains including the strain of the reference genome, C57BL/6J, whereas a functional protein is produced in other strains. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Restricted expression toward large intestine adult (RPKM 41.5) See more
    Orthologs
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    Genomic context

    See Pla2g2a in Genome Data Viewer
    Location:
    4 D3; 4 70.57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138559168..138562500)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138831857..138835189)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32871 Neighboring gene phospholipase A2, group IID Neighboring gene STARR-seq mESC enhancer starr_11818 Neighboring gene phospholipase A2, group V Neighboring gene predicted gene, 25280 Neighboring gene STARR-positive B cell enhancer mm9_chr4:138412463-138412764 Neighboring gene STARR-positive B cell enhancer mm9_chr4:138422386-138422686 Neighboring gene predicted gene, 32930 Neighboring gene predicted gene 13030

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Spontaneous (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent phospholipase A2 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intestinal stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    NOT acts_upstream_of_or_within negative regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in phosphatidic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylcholine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylethanolamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylethanolamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of endothelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of epithelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of neutrophil activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neutrophil activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within somatic stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phospholipase A2, membrane associated
    Names
    GIIC sPLA2
    enhancing factor
    group IIA phospholipase A2
    modifier of Min1
    non-pancreatic secreted type II phospholipase A2
    phosphatidylcholine 2-acylhydrolase 2A
    secretory group II phospholipase A2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082531.1NP_001076000.1  phospholipase A2, membrane associated precursor

      See identical proteins and their annotated locations for NP_001076000.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, coding) contains a gap in the coding region to represent the functional allele that is not present in the the strain of the reference genome, C57BL/6J.
      Source sequence(s)
      BC045156
      UniProtKB/Swiss-Prot
      P31482, Q60871
      UniProtKB/TrEMBL
      V5TDK8, V5TDL3
      Conserved Domains (1) summary
      smart00085
      Location:22139
      PA2c; Phospholipase A2

    RNA

    1. NR_002926.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, non-coding) represents the non-functional allele that is present in several strains, including the strain of the reference genome, C57BL/6J. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, coding, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK131857, CB933893
      Related
      ENSMUST00000135748.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      138559168..138562500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_011108.1: Suppressed sequence

      Description
      NM_011108.1: This RefSeq was permanently suppressed because it contains a frame-shift, which results in premature translation termination, thus rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD).