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    Ppp1r3a protein phosphatase 1, regulatory subunit 3A [ Mus musculus (house mouse) ]

    Gene ID: 140491, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ppp1r3aprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 3Aprovided by MGI
    Primary source
    MGI:MGI:2153588
    See related
    Ensembl:ENSMUSG00000042717 AllianceGenome:MGI:2153588
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GM; RG1; RGL
    Summary
    Predicted to enable glycogen binding activity; protein phosphatase 1 binding activity; and protein serine/threonine phosphatase activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to act upstream of or within glycogen metabolic process. Predicted to be located in membrane. Predicted to be part of protein phosphatase type 1 complex. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to human PPP1R3A (protein phosphatase 1 regulatory subunit 3A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 3.3) and mammary gland adult (RPKM 0.6) See more
    Orthologs
    NEW
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    Genomic context

    See Ppp1r3a in Genome Data Viewer
    Location:
    6 A1; 6 6.31 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (14713821..14755273, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (14713822..14755274, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15213 Neighboring gene STARR-seq mESC enhancer starr_15214 Neighboring gene predicted gene, 23013 Neighboring gene STARR-seq mESC enhancer starr_15216 Neighboring gene STARR-seq mESC enhancer starr_15217 Neighboring gene STARR-seq mESC enhancer starr_15218 Neighboring gene predicted gene, 38768 Neighboring gene STARR-seq mESC enhancer starr_15219 Neighboring gene STARR-seq mESC enhancer starr_15220 Neighboring gene predicted gene, 36300 Neighboring gene forkhead box P2 Neighboring gene ribosomal protein L13 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC124391, MGC124392

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein phosphatase 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glycogen metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein phosphatase type 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 3A
    Names
    protein phosphatase 1 glycogen-associated regulatory subunit
    protein phosphatase 1, regulatory (inhibitor) subunit 3A
    protein phosphatase type-1 glycogen targeting subunit
    NP_536712.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080464.2NP_536712.2  protein phosphatase 1 regulatory subunit 3A

      See identical proteins and their annotated locations for NP_536712.2

      Status: VALIDATED

      Source sequence(s)
      AC140470, AK084518, BC109007
      Consensus CDS
      CCDS19917.1
      UniProtKB/Swiss-Prot
      Q32MS0, Q8BUJ4, Q8BUL0, Q99MR9
      Related
      ENSMUSP00000049054.5, ENSMUST00000045096.6
      Conserved Domains (1) summary
      pfam03370
      Location:124230
      CBM_21; Carbohydrate/starch-binding module (family 21)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      14713821..14755273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)