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    Hoxa3 homeobox A3 [ Mus musculus (house mouse) ]

    Gene ID: 15400, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hoxa3provided by MGI
    Official Full Name
    homeobox A3provided by MGI
    Primary source
    MGI:MGI:96175
    See related
    Ensembl:ENSMUSG00000079560 AllianceGenome:MGI:96175
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mo-10; Hox-1.5
    Summary
    Enables DNA-binding transcription factor activity and HMG box domain binding activity. Acts upstream of or within several processes, including endocrine system development; regionalization; and skeletal system development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; embryo mesenchyme; genitourinary system; gut; and nervous system. Used to study DiGeorge syndrome. Orthologous to human HOXA3 (homeobox A3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in colon adult (RPKM 3.5), ovary adult (RPKM 2.4) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hoxa3 in Genome Data Viewer
    Location:
    6 B3; 6 25.4 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (52146039..52190316, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (52169059..52213067, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Hoxa transcript antisense RNA, myeloid-specific 2 Neighboring gene Hoxa transcript antisense RNA, myeloid-specific 1 Neighboring gene homeobox A2 Neighboring gene Hoxa cluster antisense RNA 2 Neighboring gene RIKEN cDNA 5730596B20 gene Neighboring gene predicted gene 15050 Neighboring gene predicted gene, 57749 Neighboring gene homeobox A4 Neighboring gene Hoxa cluster antisense RNA 3 Neighboring gene homeobox A5 Neighboring gene homeobox A6 Neighboring gene homeobox A7 Neighboring gene mistral long non-coding RNA Neighboring gene predicted gene, 57855 Neighboring gene homeobox A9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (9)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within animal organ formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cartilage development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryonic skeletal system morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within embryonic skeletal system morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of gene expression TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within glossopharyngeal nerve morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within glossopharyngeal nerve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within parathyroid gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of parathyroid gland development TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within specification of animal organ position IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within thymus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within thymus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of thymus development TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within thyroid gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within thyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    homeobox protein Hox-A3
    Names
    homeo box A3
    homeobox protein Hox-1.5
    homeobox protein MO-10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010452.4NP_034582.1  homeobox protein Hox-A3

      See identical proteins and their annotated locations for NP_034582.1

      Status: VALIDATED

      Source sequence(s)
      AC015583, AC091106
      Consensus CDS
      CCDS20140.1
      UniProtKB/Swiss-Prot
      P02831, Q4V9Z8, Q61197
      Related
      ENSMUSP00000110077.3, ENSMUST00000114434.9
      Conserved Domains (3) summary
      COG5576
      Location:182309
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:196249
      Homeobox; Homeobox domain
      pfam13293
      Location:378441
      DUF4074; Domain of unknown function (DUF4074)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      52146039..52190316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321404.3XP_017176893.1  homeobox protein Hox-A3 isoform X1

      UniProtKB/Swiss-Prot
      P02831, Q4V9Z8, Q61197
      Conserved Domains (3) summary
      COG5576
      Location:182309
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:196249
      Homeobox; Homeobox domain
      pfam13293
      Location:378441
      DUF4074; Domain of unknown function (DUF4074)
    2. XM_017321403.2XP_017176892.1  homeobox protein Hox-A3 isoform X1

      UniProtKB/Swiss-Prot
      P02831, Q4V9Z8, Q61197
      Conserved Domains (3) summary
      COG5576
      Location:182309
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:196249
      Homeobox; Homeobox domain
      pfam13293
      Location:378441
      DUF4074; Domain of unknown function (DUF4074)
    3. XM_017321402.2XP_017176891.1  homeobox protein Hox-A3 isoform X1

      UniProtKB/Swiss-Prot
      P02831, Q4V9Z8, Q61197
      Conserved Domains (3) summary
      COG5576
      Location:182309
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:196249
      Homeobox; Homeobox domain
      pfam13293
      Location:378441
      DUF4074; Domain of unknown function (DUF4074)
    4. XM_011241225.4XP_011239527.1  homeobox protein Hox-A3 isoform X1

      See identical proteins and their annotated locations for XP_011239527.1

      UniProtKB/Swiss-Prot
      P02831, Q4V9Z8, Q61197
      Conserved Domains (3) summary
      COG5576
      Location:182309
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:196249
      Homeobox; Homeobox domain
      pfam13293
      Location:378441
      DUF4074; Domain of unknown function (DUF4074)