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    Mesd mesoderm development LRP chaperone [ Mus musculus (house mouse) ]

    Gene ID: 67943, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mesdprovided by MGI
    Official Full Name
    mesoderm development LRP chaperoneprovided by MGI
    Primary source
    MGI:MGI:1891421
    See related
    Ensembl:ENSMUSG00000038503 AllianceGenome:MGI:1891421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    msd; mesd; Mesdc2; mKIAA0081; 2210015O11Rik
    Summary
    Enables identical protein binding activity and low-density lipoprotein particle receptor binding activity. Involved in phagocytosis and positive regulation of skeletal muscle acetylcholine-gated channel clustering. Acts upstream of or within protein folding and protein localization to cell surface. Located in plasma membrane. Is expressed in several structures, including 4-cell stage embryo; genitourinary system; hemolymphoid system; liver; and ventricular layer. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 20. Orthologous to human MESD (mesoderm development LRP chaperone). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.6), adrenal adult (RPKM 2.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mesd in Genome Data Viewer
    Location:
    7 48.35 cM; 7 D3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (83533074..83549519)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (83883866..83900311)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm729 Neighboring gene predicted gene, 39043 Neighboring gene STARR-seq mESC enhancer starr_19412 Neighboring gene STARR-seq mESC enhancer starr_19413 Neighboring gene RIKEN cDNA 3110009M11 gene Neighboring gene STARR-seq mESC enhancer starr_19414 Neighboring gene STARR-positive B cell enhancer ABC_E9696 Neighboring gene STARR-positive B cell enhancer ABC_E448 Neighboring gene talin rod domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_19417 Neighboring gene STARR-seq mESC enhancer starr_19418 Neighboring gene cell migration inducing protein, hyaluronan binding Neighboring gene predicted gene, 30440 Neighboring gene STARR-seq mESC enhancer starr_19420 Neighboring gene STARR-seq mESC enhancer starr_19424 Neighboring gene STARR-seq mESC enhancer starr_19425 Neighboring gene STARR-seq mESC enhancer starr_19426 Neighboring gene abhydrolase domain containing 17C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    mesoderm development
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC25959

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables low-density lipoprotein particle receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables low-density lipoprotein particle receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesoderm development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ossification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    LRP chaperone MESD
    Names
    LDLR chaperone MESD
    mesoderm development candidate 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374090.1NP_001361019.1  LRP chaperone MESD isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154141
    2. NM_023403.4NP_075892.3  LRP chaperone MESD isoform 1 precursor

      See identical proteins and their annotated locations for NP_075892.3

      Status: VALIDATED

      Source sequence(s)
      AC154141
      Consensus CDS
      CCDS21415.1
      UniProtKB/Swiss-Prot
      Q8C611, Q8CCX7, Q91WK8, Q9CVB9, Q9ERE7
      Related
      ENSMUSP00000091768.4, ENSMUST00000094215.10
      Conserved Domains (1) summary
      pfam10185
      Location:43192
      Mesd; Chaperone for wingless signalling and trafficking of LDL receptor

    RNA

    1. NR_164323.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154141
    2. NR_164324.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154141
    3. NR_164325.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154141

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      83533074..83549519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)