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    Wrn Werner syndrome RecQ like helicase [ Mus musculus (house mouse) ]

    Gene ID: 22427, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wrnprovided by MGI
    Official Full Name
    Werner syndrome RecQ like helicaseprovided by MGI
    Primary source
    MGI:MGI:109635
    See related
    Ensembl:ENSMUSG00000031583 AllianceGenome:MGI:109635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables 3'-5' exonuclease activity. Involved in DNA replication and G-quadruplex DNA unwinding. Acts upstream of or within several processes, including determination of adult lifespan; regulation of growth rate; and replicative senescence. Located in chromosome, telomeric region; nucleoplasm; and replication fork. Is expressed in coelomic epithelium of testis; metanephros; and spleen. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Orthologous to human WRN (WRN RecQ like helicase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 4.4), liver E14.5 (RPKM 3.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Wrn in Genome Data Viewer
    Location:
    8 A3; 8 20.3 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (33724400..33875591, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33234372..33385543, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33281 Neighboring gene STARR-seq mESC enhancer starr_21099 Neighboring gene STARR-seq mESC enhancer starr_21100 Neighboring gene GTP-binding protein 10 (putative) pseudogene Neighboring gene STARR-seq mESC enhancer starr_21101 Neighboring gene STARR-seq mESC enhancer starr_21102 Neighboring gene purine-rich element binding protein G Neighboring gene translocase of outer mitochondrial membrane 40 homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (6) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3'-5' exonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3'-5' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3'-5' exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 3'-flap-structured DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3'-flap-structured DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables 8-hydroxy-2'-deoxyguanosine DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables 8-hydroxy-2'-deoxyguanosine DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-quadruplex DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MutLalpha complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MutLalpha complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Y-form DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Y-form DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables bubble DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables bubble DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables forked DNA-dependent helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables four-way junction DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables four-way junction helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables telomeric D-loop binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables telomeric D-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomeric G-quadruplex DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables telomeric G-quadruplex DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA synthesis involved in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA synthesis involved in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G-quadruplex DNA unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G-quadruplex DNA unwinding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in G-quadruplex DNA unwinding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in G-quadruplex DNA unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to gamma radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of strand invasion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of strand invasion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of growth rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in replication fork processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within replicative senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to UV-C IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to UV-C ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within telomere maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomeric D-loop disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in telomeric D-loop disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome, telomeric region IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in replication fork IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
    Names
    Werner syndrome ATP-dependent helicase homolog
    Werner syndrome homolog
    Werner syndrome protein homolog
    exonuclease WRN
    NP_001116294.1
    NP_035851.3
    XP_006509154.1
    XP_006509156.1
    XP_017168151.1
    XP_036009773.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122822.1NP_001116294.1  bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

      See identical proteins and their annotated locations for NP_001116294.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK052466, AK162801, AK171490, BC050921
      Consensus CDS
      CCDS22229.1
      UniProtKB/Swiss-Prot
      O09050, O09053, Q80YP9, Q9JKD4, Q9Z241, Q9Z242
      UniProtKB/TrEMBL
      A0A1B0GR54
      Related
      ENSMUSP00000033991.7, ENSMUST00000033991.13
      Conserved Domains (5) summary
      smart00341
      Location:11161194
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:502975
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      TIGR01388
      Location:156344
      rnd; ribonuclease D
      cd06129
      Location:55223
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:12231317
      HTH_40; Helix-turn-helix domain
    2. NM_011721.4NP_035851.3  bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

      See identical proteins and their annotated locations for NP_035851.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK052466, AK162801, AK171490, BC050921
      Consensus CDS
      CCDS22229.1
      UniProtKB/Swiss-Prot
      O09050, O09053, Q80YP9, Q9JKD4, Q9Z241, Q9Z242
      UniProtKB/TrEMBL
      A0A1B0GR54
      Related
      ENSMUSP00000033990.6, ENSMUST00000033990.7
      Conserved Domains (5) summary
      smart00341
      Location:11161194
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:502975
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      TIGR01388
      Location:156344
      rnd; ribonuclease D
      cd06129
      Location:55223
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:12231317
      HTH_40; Helix-turn-helix domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      33724400..33875591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509093.5XP_006509156.1  bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X2

      UniProtKB/TrEMBL
      A0A1B0GR54
      Conserved Domains (4) summary
      smart00341
      Location:11151193
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:501974
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      cd06129
      Location:55223
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:12221316
      HTH_40; Helix-turn-helix domain
    2. XM_006509091.5XP_006509154.1  bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X1

      See identical proteins and their annotated locations for XP_006509154.1

      UniProtKB/Swiss-Prot
      O09050, O09053, Q80YP9, Q9JKD4, Q9Z241, Q9Z242
      UniProtKB/TrEMBL
      A0A1B0GR54
      Conserved Domains (5) summary
      smart00341
      Location:11161194
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:502975
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      TIGR01388
      Location:156344
      rnd; ribonuclease D
      cd06129
      Location:55223
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:12231317
      HTH_40; Helix-turn-helix domain
    3. XM_036153880.1XP_036009773.1  bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X2

      UniProtKB/TrEMBL
      A0A1B0GR54
      Conserved Domains (4) summary
      smart00341
      Location:11151193
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:501974
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      cd06129
      Location:55223
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:12221316
      HTH_40; Helix-turn-helix domain
    4. XM_017312662.3XP_017168151.1  bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X1

      UniProtKB/Swiss-Prot
      O09050, O09053, Q80YP9, Q9JKD4, Q9Z241, Q9Z242
      UniProtKB/TrEMBL
      A0A1B0GR54
      Conserved Domains (5) summary
      smart00341
      Location:11161194
      HRDC; Helicase and RNase D C-terminal
      TIGR00614
      Location:502975
      recQ_fam; ATP-dependent DNA helicase, RecQ family
      TIGR01388
      Location:156344
      rnd; ribonuclease D
      cd06129
      Location:55223
      RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
      pfam14493
      Location:12231317
      HTH_40; Helix-turn-helix domain

    RNA

    1. XR_004934799.1 RNA Sequence