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    MLF2 myeloid leukemia factor 2 [ Homo sapiens (human) ]

    Gene ID: 8079, updated on 27-Nov-2024

    Summary

    Official Symbol
    MLF2provided by HGNC
    Official Full Name
    myeloid leukemia factor 2provided by HGNC
    Primary source
    HGNC:HGNC:7126
    See related
    Ensembl:ENSG00000089693 MIM:601401; AllianceGenome:HGNC:7126
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NTN4
    Summary
    Predicted to be involved in regulation of DNA-templated transcription. Located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 67.7), prostate (RPKM 51.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MLF2 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (6747996..6753141, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (6757561..6762706, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6857162..6862307, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 781, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5878 Neighboring gene COP9 signalosome subunit 7A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4182 Neighboring gene parathymosin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6887480-6888130 Neighboring gene lymphocyte activating 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    myeloid leukemia factor 2
    Names
    myelodysplasia-myeloid leukemia factor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382225.1NP_001369154.1  myeloid leukemia factor 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs compared to variant 1. Variants 1, 2 and 3, all encode the same protein.
      Source sequence(s)
      AC125494
      Consensus CDS
      CCDS8559.1
      UniProtKB/Swiss-Prot
      Q15773
      UniProtKB/TrEMBL
      A8K1F4, Q5U0N1
      Related
      ENSP00000446317.1, ENST00000539187.5
      Conserved Domains (1) summary
      pfam10248
      Location:26199
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
    2. NM_001382226.1NP_001369155.1  myeloid leukemia factor 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3, all encode the same protein.
      Source sequence(s)
      AC125494, U57342
      Consensus CDS
      CCDS8559.1
      UniProtKB/Swiss-Prot
      Q15773
      UniProtKB/TrEMBL
      A8K1F4, Q5U0N1
      Related
      ENSP00000203630.5, ENST00000203630.10
      Conserved Domains (1) summary
      pfam10248
      Location:26199
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
    3. NM_005439.3NP_005430.1  myeloid leukemia factor 2

      See identical proteins and their annotated locations for NP_005430.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3, all encode the same protein.
      Source sequence(s)
      AK289869, BC002340
      Consensus CDS
      CCDS8559.1
      UniProtKB/Swiss-Prot
      Q15773
      UniProtKB/TrEMBL
      A8K1F4, Q5U0N1
      Related
      ENSP00000403941.1, ENST00000435120.5
      Conserved Domains (1) summary
      pfam10248
      Location:26199
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      6747996..6753141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      6757561..6762706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)