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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_011531.1 RefSeqGene
- Range
-
5101..51012
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001281302.2 → NP_001268231.1 ribosome-releasing factor 2, mitochondrial isoform 4
See identical proteins and their annotated locations for NP_001268231.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
- Source sequence(s)
-
AF111808, AF367997, AY453587, BC015712, DC402212
- UniProtKB/Swiss-Prot
-
Q969S9
- Conserved Domains (6) summary
-
- cd01886
Location:104 → 384
- EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
- PRK12739
Location:98 → 809
- PRK12739; elongation factor G; Reviewed
- cd01693
Location:594 → 714
- mtEFG2_like_IV; mtEF-G2 domain IV. This subfamily is a part the of mitochondrial transcriptional elongation factor, mtEF-G2. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory ...
- cd03713
Location:719 → 795
- EFG_mtEFG_C; EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2 ...
- cd04092
Location:399 → 480
- mtEFG2_II_like; Domain II of mitochondrial elongation factor G2-like proteins found in eukaryotes
- cd16262
Location:518 → 593
- EFG_III; Domain III of Elongation Factor G (EFG)
-
NM_032380.5 → NP_115756.2 ribosome-releasing factor 2, mitochondrial isoform 1
See identical proteins and their annotated locations for NP_115756.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) lacks an alternate exon in the 5' coding region and initiates translation at a downstream start codon, compared to variant 4. It encodes isoform 1 which is shorter at the N-terminus, compared to isoform 4.
- Source sequence(s)
-
AF111808, AF367997, AK315705, AY453587
- Consensus CDS
-
CCDS4023.1
- UniProtKB/Swiss-Prot
- A0AR28, Q8N6D8, Q8WYI0, Q969S9, Q9H6Z1
- Related
- ENSP00000296805.3, ENST00000296805.8
- Conserved Domains (1) summary
-
- cl27769
Location:66 → 777
- GTP_EFTU; Elongation factor Tu GTP binding domain
-
NM_170681.3 → NP_733781.1 ribosome-releasing factor 2, mitochondrial isoform 3
See identical proteins and their annotated locations for NP_733781.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, contains an alternate 3' terminal exon and initiates translation at a downstream start codon, compared to variant 4. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 4.
- Source sequence(s)
-
AA418187, AF111808, AK025314
- Consensus CDS
-
CCDS47232.1
- UniProtKB/Swiss-Prot
-
Q969S9
- Related
- ENSP00000405808.2, ENST00000427854.6
- Conserved Domains (3) summary
-
- cd01886
Location:72 → 352
- EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
- pfam00009
Location:69 → 351
- GTP_EFTU; Elongation factor Tu GTP binding domain
- cd04092
Location:367 → 448
- mtEFG2_II_like; Domain II of mitochondrial elongation factor G2-like proteins found in eukaryotes
-
NM_170691.3 → NP_733792.1 ribosome-releasing factor 2, mitochondrial isoform 2
See identical proteins and their annotated locations for NP_733792.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks two alternate exons in the 5' coding region and initiates translation at a downstream start codon, compared to variant 4. It encodes isoform 2, which is shorter than isoform 4.
- Source sequence(s)
-
AF111808, AY453587
- Consensus CDS
-
CCDS4024.1
- Related
- ENSP00000296804.3, ENST00000345239.6
- Conserved Domains (6) summary
-
- cd01886
Location:72 → 352
- EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
- PRK12739
Location:66 → 713
- PRK12739; elongation factor G; Reviewed
- cd01693
Location:515 → 635
- mtEFG2_like_IV; mtEF-G2 domain IV. This subfamily is a part the of mitochondrial transcriptional elongation factor, mtEF-G2. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory ...
- cd03713
Location:640 → 716
- EFG_mtEFG_C; EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2 ...
- cd16262
Location:439 → 514
- EFG_III; Domain III of Elongation Factor G (EFG)
- cl02787
Location:361 → 401
- Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins
RNA
-
NR_104006.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AF111808, AF367997, AK025314, AY453587, DC402212
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000005.10 Reference GRCh38.p14 Primary Assembly
- Range
-
74721206..74767117 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047417835.1 → XP_047273791.1 ribosome-releasing factor 2, mitochondrial isoform X2
-
XM_017009986.2 → XP_016865475.1 ribosome-releasing factor 2, mitochondrial isoform X1
- UniProtKB/Swiss-Prot
- A0AR28, Q8N6D8, Q8WYI0, Q969S9, Q9H6Z1
- Conserved Domains (1) summary
-
- cl27769
Location:66 → 777
- GTP_EFTU; Elongation factor Tu GTP binding domain
-
XM_047417834.1 → XP_047273790.1 ribosome-releasing factor 2, mitochondrial isoform X2
-
XM_047417833.1 → XP_047273789.1 ribosome-releasing factor 2, mitochondrial isoform X1
- UniProtKB/Swiss-Prot
- A0AR28, Q8N6D8, Q8WYI0, Q969S9, Q9H6Z1
-
XM_011543691.4 → XP_011541993.1 ribosome-releasing factor 2, mitochondrial isoform X3
- UniProtKB/TrEMBL
-
A0A6M4C975
- Conserved Domains (4) summary
-
- cd01886
Location:72 → 352
- EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
- pfam00009
Location:69 → 351
- GTP_EFTU; Elongation factor Tu GTP binding domain
- cd04092
Location:367 → 448
- mtEFG2_II_like; Domain II of mitochondrial elongation factor G2-like proteins found in eukaryotes
- cl20541
Location:486 → 529
- EFG_III-like; Domain III of Elongation factor G (EF-G) and related proteins
Alternate T2T-CHM13v2.0
Genomic
-
NC_060929.1 Alternate T2T-CHM13v2.0
- Range
-
75202108..75248032 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054353698.1 → XP_054209673.1 ribosome-releasing factor 2, mitochondrial isoform X2
-
XM_054353696.1 → XP_054209671.1 ribosome-releasing factor 2, mitochondrial isoform X1
-
XM_054353697.1 → XP_054209672.1 ribosome-releasing factor 2, mitochondrial isoform X2
-
XM_054353695.1 → XP_054209670.1 ribosome-releasing factor 2, mitochondrial isoform X1
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XM_054353699.1 → XP_054209674.1 ribosome-releasing factor 2, mitochondrial isoform X3
- UniProtKB/TrEMBL
-
A0A6M4C975