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    CASC2 cancer susceptibility 2 [ Homo sapiens (human) ]

    Gene ID: 255082, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CASC2provided by HGNC
    Official Full Name
    cancer susceptibility 2provided by HGNC
    Primary source
    HGNC:HGNC:22933
    See related
    Ensembl:ENSG00000177640 MIM:608598; AllianceGenome:HGNC:22933
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C10orf5
    Summary
    Involved in defense response to tumor cell; negative regulation of MAPK cascade; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thyroid (RPKM 1.0), brain (RPKM 1.0) and 22 other tissues See more
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    Genomic context

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    See CASC2 in Genome Data Viewer
    Location:
    10q26.11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (118046821..118210153)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (118940870..119104994)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (119806332..119969665)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2674 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:119545298-119545468 Neighboring gene VISTA enhancer hs1236 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:119597764-119598550 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:119658461-119659162 Neighboring gene uncharacterized LOC105378504 Neighboring gene VISTA enhancer hs1551 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:119739304-119740503 Neighboring gene RAB11 family interacting protein 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:119795138-119795331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2863 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:119907111-119907355 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:119963650-119964234 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:119964235-119964819 Neighboring gene Sharpr-MPRA regulatory region 3281 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:119973305-119974504 Neighboring gene long intergenic non-protein coding RNA 2944 Neighboring gene NANOG hESC enhancer GRCh37_chr10:120025545-120026208 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120044911-120045412 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120045413-120045912 Neighboring gene VISTA enhancer hs672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120101641-120102140 Neighboring gene family with sequence similarity 204 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA CASC2 Interacts With miR-181a to Modulate Glioma Growth and Resistance to TMZ Through PTEN Pathway. Liao Y, et al. J Cell Biochem, 2017 Jul. PMID 28121023
    2. Long noncoding RNA CASC2c inhibited cell proliferation in hepatocellular carcinoma by inactivated ERK1/2 and Wnt/β-catenin signaling pathway. Li QY, et al. Clin Transl Oncol, 2020 Mar. PMID 31625123
    3. Overexpression of long non-coding RNA cancer susceptibility 2 inhibits cell invasion and angiogenesis in gastric cancer. Zhou J, et al. Mol Med Rep, 2017 Oct. PMID 28849111, Free PMC Article
    4. LncRNA CASC 2 is upregulated in aphthous stomatitis and predicts the recurrence. Lu J, et al. BMC Oral Health, 2020 Jan 14. PMID 31937279, Free PMC Article
    5. lncRNA CASC2 downregulation participates in rheumatoid arthritis, and CASC2 overexpression promotes the apoptosis of fibroblast‑like synoviocytes by downregulating IL‑17. Liu C, et al. Mol Med Rep, 2020 May. PMID 32186765, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer.
      Title: POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer.
    2. Long noncoding RNA CASC2 protect ROS-induced oxidative stress in myocardial infarction by miR-18a/SIRT2.
      Title: Long noncoding RNA CASC2 protect ROS-induced oxidative stress in myocardial infarction by miR-18a/SIRT2.
    3. Potential of circulating lncRNA CASC2 as a biomarker in reflecting the inflammatory cytokines, multi-organ dysfunction, disease severity, and mortality in sepsis patients.
      Title: Potential of circulating lncRNA CASC2 as a biomarker in reflecting the inflammatory cytokines, multi-organ dysfunction, disease severity, and mortality in sepsis patients.
    4. Long Noncoding RNA CASC2 Facilitated Wound Healing through miRNA-155/HIF-1alpha in Diabetic Foot Ulcers.
      Title: Long Noncoding RNA CASC2 Facilitated Wound Healing through miRNA-155/HIF-1α in Diabetic Foot Ulcers.
    5. LncRNA CASC2 Alleviates Sepsis-induced Acute Lung Injury by Regulating the miR-152-3p/PDK4 Axis.
      Title: LncRNA CASC2 Alleviates Sepsis-induced Acute Lung Injury by Regulating the miR-152-3p/PDK4 Axis.
    6. Abnormal expression and clinical value analysis of long noncoding RNA cancer susceptibility candidate 2 in children with severe pneumonia complicated with respiratory failure.
      Title: Abnormal expression and clinical value analysis of long noncoding RNA cancer susceptibility candidate 2 in children with severe pneumonia complicated with respiratory failure.
    7. Transcription factor NFIC functions as a tumor suppressor in lung squamous cell carcinoma progression by modulating lncRNA CASC2.
      Title: Transcription factor NFIC functions as a tumor suppressor in lung squamous cell carcinoma progression by modulating lncRNA CASC2.
    8. [Differential Expression of Long Non-coding RNA Cancer Susceptibility Candidate 2 and Imprinted Gene H19 in Extrahepatic Cholangiocarcinoma].
      Title: [Differential Expression of Long Non-coding RNA Cancer Susceptibility Candidate 2 and Imprinted Gene H19 in Extrahepatic Cholangiocarcinoma].
    9. Long non-coding RNA cancer susceptibility candidate 2 regulates the function of human fibroblast-like synoviocytes via the microRNA-18a-5p/B-cell translocation gene 3 signaling axis in rheumatoid arthritis.
      Title: Long non-coding RNA cancer susceptibility candidate 2 regulates the function of human fibroblast-like synoviocytes via the microRNA-18a-5p/B-cell translocation gene 3 signaling axis in rheumatoid arthritis.
    10. Down-regulation of MEG3, PANDA and CASC2 as p53-related lncRNAs in breast cancer.
      Title: Down-regulation of MEG3, PANDA and CASC2 as p53-related lncRNAs in breast cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (69)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • cancer susceptibility 2 (non-protein coding)
    • cancer susceptibility candidate 2 (non-protein coding)

    Clone Names

    • MGC117219

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in defense response to tumor cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026939.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC005879, AC022395, AI219353, BC036393, BC112306
      Related
      ENST00000435944.5

    2. NR_026940.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' region, compared to variant 1.
      Source sequence(s)
      AC005879, AC022395, AI219353, AJ535621, BC036393
      Related
      ENST00000665675.1

    3. NR_026941.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 3' splice pattern, compared to variant 1.
      Source sequence(s)
      AC022395, AJ344228, BC036393, BC112326

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      118046821..118210153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      118940870..119104994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178816.2: Suppressed sequence

      Description
      NM_178816.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

    2. NM_201377.1: Suppressed sequence

      Description
      NM_201377.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6XLA1.1 GenPept UniProtKB/Swiss-Prot:Q6XLA1
    Q8IU53.1 GenPept UniProtKB/Swiss-Prot:Q8IU53

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials