Ipo8 importin 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ipo8provided by MGI
Official Full Name: importin 8provided by MGI
Primary source: MGI:MGI:2444611
See related: Ensembl:ENSMUSG00000040029 AllianceGenome:MGI:2444611
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Om1; MRP7; OM-1; Abcc10; Ranbp8; 6230418K12Rik; C130009K11Rik
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in protein import into nucleus. Predicted to be located in plasma membrane. Predicted to be active in cytosol and nuclear envelope. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system. Orthologous to human IPO8 (importin 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 7.3), bladder adult (RPKM 7.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G3; 6 78.57 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (148672181..148732977, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (148770683..148832931, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Importin 8 plays a critical role in mediating the cytoplasm-to-nucleus transport of mature miRNAs. IPO8-mediated nuclear transport of mature miRNAs is also dependent on the association of IPO8 with the Argonaute 2 complex.
Title: Importin 8 regulates the transport of mature microRNAs into the cell nucleus.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase-coupled transmembrane transporter activity	ISA Inferred from Sequence Alignment more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transport	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISA Inferred from Sequence Alignment more info	PubMed

General protein information

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Preferred Names: importin-8

Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 10; imp8; oocyte maturation 1; ran-binding protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081113.2 → NP_001074582.1 importin-8 isoform 1

See identical proteins and their annotated locations for NP_001074582.1

Status: VALIDATED

Source sequence(s)

AC134542

Consensus CDS

CCDS39719.1

UniProtKB/Swiss-Prot

B2KGD8, Q7TMY7, Q811I3, Q8C8A9, Q8R2P6, Q8R3V7

Related

ENSMUSP00000046759.8, ENSMUST00000048418.14

Conserved Domains (3) summary

COG5656
Location:15 → 995

SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]

pfam03378
Location:626 → 869

CAS_CSE1; CAS/CSE protein, C-terminus

pfam03810
Location:22 → 101

IBN_N; Importin-beta N-terminal domain
NM_001418294.1 → NP_001405223.1 importin-8 isoform 2

Status: VALIDATED

Source sequence(s)

AC134542
NM_001418295.1 → NP_001405224.1 importin-8 isoform 3

Status: VALIDATED

Source sequence(s)

AC134542
NM_001418296.1 → NP_001405225.1 importin-8 isoform 4

Status: VALIDATED

Source sequence(s)

AC134542