KIN4 putative serine/threonine protein kinase KIN4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: KIN4
Official Full Name: putative serine/threonine protein kinase KIN4
Primary source: SGD:S000005759
Locus tag: YOR233W
See related: AllianceGenome:SGD:S000005759; FungiDB:YOR233W; VEuPathDB:YOR233W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: KIN3; KIN31
Summary: Enables protein serine/threonine kinase activity. Involved in mitotic spindle orientation checkpoint signaling and protein localization to spindle pole body. Acts upstream of or within peroxisome inheritance and vacuole inheritance. Located in cell cortex; cellular bud neck; and spindle pole body. Human ortholog(s) of this gene implicated in anencephaly and uterine fibroid. Orthologous to human NUAK1 (NUAK family kinase 1) and NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See KIN4 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (775846..778248)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spindle Position Checkpoint Kinase Kin4 Regulates Organelle Transport in Saccharomyces cerevisiae.
Title: Spindle Position Checkpoint Kinase Kin4 Regulates Organelle Transport in Saccharomyces cerevisiae.
Data show that bud-localized MEN regulator Lte1 prevents Kin4 that escapes into the bud from associating with SPBs in the daughter cell.
Title: Lte1 promotes mitotic exit by controlling the localization of the spindle position checkpoint kinase Kin4.
Data suggest that Lte1 promotes mitotic exit by inhibiting Kin4 activity at the daughter spindle pole body.
Title: The cortical protein Lte1 promotes mitotic exit by inhibiting the spindle position checkpoint kinase Kin4.
The bud neck-associated kinase Elm1 participates in Kin4 activation and SPOC signaling by phosphorylating a conserved residue within the activation loop of Kin4.
Title: Elm1 kinase activates the spindle position checkpoint kinase Kin4.
show that the protein phosphatase functions upstream of Kin4, regulating the kinase's phosphorylation and localization during an unperturbed cell cycle and during SPOC activation, thus defining the phosphatase as a key regulator of SPOC function
Title: The protein phosphatase 2A functions in the spindle position checkpoint by regulating the checkpoint kinase Kin4.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle orientation checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peroxisome inheritance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within peroxisome inheritance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to spindle pole body	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vacuole inheritance	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: putative serine/threonine protein kinase KIN4

NP_014876.1

EC 2.7.11.1

Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint (SPOC) is activated; regulates peroxisomal transport and vacuolar inheritance along with Frk1p; protects the peroxisomal Myo2p receptor Inp2p from degradation in mother cells along with Frk1p; localizes asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

775846..778248

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183652.1 → NP_014876.1 TPA: putative serine/threonine protein kinase KIN4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014876.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2T7, Q01919

UniProtKB/TrEMBL

A6ZP74, B3LJQ5, B5VSB4, C7GWF1, C8ZGY7, N1NWU2

Conserved Domains (1) summary

cd14076
Location:44 → 313

STKc_Kin4; Catalytic domain of the yeast Serine/Threonine Kinase, Kin4