LRRFIP2 LRR binding FLII interacting protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LRRFIP2provided by HGNC
Official Full Name: LRR binding FLII interacting protein 2provided by HGNC
Primary source: HGNC:HGNC:6703
See related: Ensembl:ENSG00000093167 MIM:614043; AllianceGenome:HGNC:6703
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HUFI-2
Summary: The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
Expression: Ubiquitous expression in testis (RPKM 17.9), heart (RPKM 16.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p22.2

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (37052626..37176360, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (37053969..37177703, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (37094117..37217851, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the ability of Ca(2+) to accentuate the activity of NLRP3 inflammasome is abrogated in Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2)-knockdown macrophages.
Title: F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2.
FATylation of LRRFIP2 occurs on two distinct sites, each being modified by a single FAT10 moiety.
Title: Modification of the inflammatory mediator LRRFIP2 by the ubiquitin-like protein FAT10 inhibits its activity during cellular response to LPS.
A novel exonic rearrangement affecting MLH1 and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families
Title: A novel exonic rearrangement affecting MLH1 and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families.
Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling.
Title: Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
LRR-binding MyD88 interactor LRRFIP2 is a positive regulator of NF-kappa B activity and is also a positive regulator of cytokine production in lipopolysaccharide-stimulated macrophages, suggesting a functional role in TLR4-mediated inflammatory response.
Title: Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins.
These data suggest that LRRFIP2 plays an important role in transducing Wnt signals.
Title: Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

LRRFIP2_8913 (e-PCR)
- UniSTS:467753

RH66486 (e-PCR)
- UniSTS:55867

G54146 (e-PCR)
- UniSTS:109383

RH66477 (e-PCR)
- UniSTS:65877

STS-N68834 (e-PCR)
- UniSTS:54102

WI-19620 (e-PCR)
- UniSTS:74370

D3S4239 (e-PCR)
- UniSTS:41374

RH16680 (e-PCR)
- UniSTS:11435

STS-W88502 (e-PCR)
- UniSTS:39618

RH125441 (e-PCR)
- UniSTS:162261

Clone Names

FLJ20248, FLJ22683, FLJ58304, DKFZp434H2035

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables LRR domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leucine-rich repeat flightless-interacting protein 2

Names: LRR FLII-interacting protein 2; leucine rich repeat (in FLII) interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_053016.1 RefSeqGene

Range

7236..129192

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001134369.2 → NP_001127841.1 leucine-rich repeat flightless-interacting protein 2 isoform k

See identical proteins and their annotated locations for NP_001127841.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (k, also known as 3) is shorter, compared to isoform a.

Source sequence(s)

AK024692, BC017703, DC336346, R27776

Consensus CDS

CCDS46791.1

UniProtKB/Swiss-Prot

Q9Y608

Related

ENSP00000416364.2, ENST00000421276.6

Conserved Domains (2) summary

pfam04111
Location:329 → 424

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 349

LRRFIP; LRRFIP family
NM_001282691.1 → NP_001269620.1 leucine-rich repeat flightless-interacting protein 2 isoform d

See identical proteins and their annotated locations for NP_001269620.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (d, also known as 4) is shorter, compared to isoform a.

Source sequence(s)

AK024692, AK302282, DB033703, R27776

Consensus CDS

CCDS63592.1

UniProtKB/Swiss-Prot

Q9Y608

Related

ENSP00000379705.2, ENST00000396428.6

Conserved Domains (1) summary

pfam09738
Location:130 → 428

DUF2051; Double stranded RNA binding protein (DUF2051)
NM_001348297.1 → NP_001335226.1 leucine-rich repeat flightless-interacting protein 2 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (5) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.

Source sequence(s)

AC006583, AC126118

Conserved Domains (2) summary

pfam04111
Location:525 → 620

APG6; Autophagy protein Apg6

pfam09738
Location:246 → 545

LRRFIP; LRRFIP family
NM_001348298.1 → NP_001335227.1 leucine-rich repeat flightless-interacting protein 2 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (6) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.

Source sequence(s)

AC006583, AC126118

Conserved Domains (2) summary

pfam04111
Location:455 → 550

APG6; Autophagy protein Apg6

pfam09738
Location:152 → 475

LRRFIP; LRRFIP family
NM_001348299.1 → NP_001335228.1 leucine-rich repeat flightless-interacting protein 2 isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (7) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a. Variants 7 and 8 both encode the same isoform (e).

Source sequence(s)

AC006583, AC126118

Conserved Domains (2) summary

pfam04111
Location:397 → 492

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 417

LRRFIP; LRRFIP family
NM_001348300.1 → NP_001335229.1 leucine-rich repeat flightless-interacting protein 2 isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (8) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a. Variants 7 and 8 both encode the same isoform (e).

Source sequence(s)

AC006583, AC126118

Conserved Domains (2) summary

pfam04111
Location:397 → 492

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 417

LRRFIP; LRRFIP family
NM_001348301.1 → NP_001335230.1 leucine-rich repeat flightless-interacting protein 2 isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (9) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (f) is shorter, compared to isoform a. Variants 9 and 10 both encode the same isoform (f).

Source sequence(s)

AC006583, AC126118

Conserved Domains (2) summary

pfam09738
Location:47 → 414

LRRFIP; LRRFIP family

cl25732
Location:187 → 488

SMC_N; RecF/RecN/SMC N terminal domain
NM_001348302.1 → NP_001335231.1 leucine-rich repeat flightless-interacting protein 2 isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (10) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (f) is shorter, compared to isoform a. Variants 9 and 10 both encode the same isoform (f).

Source sequence(s)

AC006583, AC126118

Conserved Domains (2) summary

pfam09738
Location:47 → 414

LRRFIP; LRRFIP family

cl25732
Location:187 → 488

SMC_N; RecF/RecN/SMC N terminal domain
NM_001348303.1 → NP_001335232.1 leucine-rich repeat flightless-interacting protein 2 isoform g

Status: REVIEWED

Description

Transcript Variant: This variant (11) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (g) is shorter, compared to isoform a.

Source sequence(s)

AC006583, AC126118

Conserved Domains (2) summary

pfam04111
Location:373 → 468

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 393

LRRFIP; LRRFIP family
NM_001348304.1 → NP_001335233.1 leucine-rich repeat flightless-interacting protein 2 isoform h

Status: REVIEWED

Description

Transcript Variant: This variant (12) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (h) is shorter, compared to isoform a.

Source sequence(s)

AC006583, AC126118

Conserved Domains (2) summary

pfam04111
Location:370 → 465

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 390

LRRFIP; LRRFIP family
NM_001348305.1 → NP_001335234.1 leucine-rich repeat flightless-interacting protein 2 isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (13) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (i) is shorter, compared to isoform a. Variants 13, 14, and 15 all encode the same isoform (i).

Source sequence(s)

AC006583, AC126118

Conserved Domains (2) summary

pfam04111
Location:363 → 458

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 383

LRRFIP; LRRFIP family
NM_001348306.1 → NP_001335235.1 leucine-rich repeat flightless-interacting protein 2 isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (14) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (i) is shorter, compared to isoform a. Variants 13, 14, and 15 all encode the same isoform (i).

Source sequence(s)

AC006583, AC126118

Conserved Domains (2) summary

pfam04111
Location:363 → 458

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 383

LRRFIP; LRRFIP family
NM_001348307.1 → NP_001335236.1 leucine-rich repeat flightless-interacting protein 2 isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (15) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (i) is shorter, compared to isoform a. Variants 13, 14, and 15 all encode the same isoform (i).

Source sequence(s)

AC006583, AC126118

Conserved Domains (2) summary

pfam04111
Location:363 → 458

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 383

LRRFIP; LRRFIP family
NM_001348308.1 → NP_001335237.1 leucine-rich repeat flightless-interacting protein 2 isoform j

Status: REVIEWED

Description

Transcript Variant: This variant (16) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (j) is shorter, compared to isoform a. Variants 16 and 17 both encode the same isoform (j).

Source sequence(s)

AC006583, AC126118

Conserved Domains (2) summary

pfam04111
Location:339 → 434

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 359

LRRFIP; LRRFIP family
NM_001348309.1 → NP_001335238.1 leucine-rich repeat flightless-interacting protein 2 isoform j

Status: REVIEWED

Description

Transcript Variant: This variant (17) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (j) is shorter, compared to isoform a. Variants 16 and 17 both encode the same isoform (j).

Source sequence(s)

AC006583, AC126118

Conserved Domains (2) summary

pfam04111
Location:339 → 434

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 359

LRRFIP; LRRFIP family
NM_001348310.1 → NP_001335239.1 leucine-rich repeat flightless-interacting protein 2 isoform k

Status: REVIEWED

Description

Transcript Variant: This variant (18) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (k) is shorter, compared to isoform a. Variants 3 and 18 both encode the same isoform (k).

Source sequence(s)

AC006583, AC126118

Consensus CDS

CCDS46791.1

UniProtKB/Swiss-Prot

Q9Y608

Related

ENSP00000405480.1, ENST00000440230.5

Conserved Domains (2) summary

pfam04111
Location:329 → 424

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 349

LRRFIP; LRRFIP family
NM_001348311.1 → NP_001335240.1 leucine-rich repeat flightless-interacting protein 2 isoform l

Status: REVIEWED

Description

Transcript Variant: This variant (19) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (l) is shorter, compared to isoform a. Variants 2 and 19 both encode the same isoform (l).

Source sequence(s)

AC006583, AC126118

Consensus CDS

CCDS2665.1

UniProtKB/Swiss-Prot

Q9Y608

Conserved Domains (2) summary

pfam04111
Location:305 → 400

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 325

LRRFIP; LRRFIP family
NM_006309.4 → NP_006300.1 leucine-rich repeat flightless-interacting protein 2 isoform a

See identical proteins and their annotated locations for NP_006300.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as 1).

Source sequence(s)

AF115509, AK024692, BC053668, R27776

Consensus CDS

CCDS2664.1

UniProtKB/Swiss-Prot

A8K649, A8MXR0, B4DY63, Q68CV3, Q9NXH5, Q9Y608

Related

ENSP00000338727.4, ENST00000336686.9

Conserved Domains (2) summary

pfam09738
Location:292 → 646

LRRFIP; LRRFIP family

pfam11932
Location:662 → 721

DUF3450; Protein of unknown function (DUF3450)
NM_017724.2 → NP_060194.1 leucine-rich repeat flightless-interacting protein 2 isoform l

See identical proteins and their annotated locations for NP_060194.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has a longer 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (l, also known as 2) is shorter, compared to isoform a.

Source sequence(s)

AK024692, BC053668, DC336346, R27776

Consensus CDS

CCDS2665.1

UniProtKB/Swiss-Prot

Q9Y608

Related

ENSP00000346349.4, ENST00000354379.8

Conserved Domains (2) summary

pfam04111
Location:305 → 400

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 325

LRRFIP; LRRFIP family

RNA

NR_145514.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (20) uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.

Source sequence(s)

AC126118

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

37052626..37176360 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006713396.2 → XP_006713459.1 leucine-rich repeat flightless-interacting protein 2 isoform X9

Conserved Domains (2) summary

pfam09738
Location:256 → 610

DUF2051; Double stranded RNA binding protein (DUF2051)

pfam13870
Location:386 → 483

DUF4201; Domain of unknown function (DUF4201)
XM_024453826.2 → XP_024309594.1 leucine-rich repeat flightless-interacting protein 2 isoform X25

UniProtKB/TrEMBL

A0A1S5UZ17

Conserved Domains (2) summary

pfam04111
Location:339 → 434

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 359

LRRFIP; LRRFIP family
XM_017007473.2 → XP_016862962.1 leucine-rich repeat flightless-interacting protein 2 isoform X21
XM_017007479.2 → XP_016862968.1 leucine-rich repeat flightless-interacting protein 2 isoform X24
XM_017007471.2 → XP_016862960.1 leucine-rich repeat flightless-interacting protein 2 isoform X19
XM_047449204.1 → XP_047305160.1 leucine-rich repeat flightless-interacting protein 2 isoform X17
XM_006713389.2 → XP_006713452.1 leucine-rich repeat flightless-interacting protein 2 isoform X5

See identical proteins and their annotated locations for XP_006713452.1

Conserved Domains (3) summary

pfam04111
Location:609 → 704

APG6; Autophagy protein Apg6

pfam04156
Location:382 → 505

IncA; IncA protein

pfam09738
Location:275 → 629

LRRFIP; LRRFIP family
XM_017007472.2 → XP_016862961.1 leucine-rich repeat flightless-interacting protein 2 isoform X20
XM_005265551.2 → XP_005265608.1 leucine-rich repeat flightless-interacting protein 2 isoform X18

Conserved Domains (1) summary

pfam09738
Location:47 → 465

DUF2051; Double stranded RNA binding protein (DUF2051)
XM_047449202.1 → XP_047305158.1 leucine-rich repeat flightless-interacting protein 2 isoform X14
XM_006713388.2 → XP_006713451.1 leucine-rich repeat flightless-interacting protein 2 isoform X4

Conserved Domains (2) summary

pfam09738
Location:276 → 630

DUF2051; Double stranded RNA binding protein (DUF2051)

pfam13870
Location:406 → 503

DUF4201; Domain of unknown function (DUF4201)
XM_006713385.2 → XP_006713448.1 leucine-rich repeat flightless-interacting protein 2 isoform X2

Conserved Domains (2) summary

pfam09738
Location:291 → 645

DUF2051; Double stranded RNA binding protein (DUF2051)

pfam13870
Location:421 → 518

DUF4201; Domain of unknown function (DUF4201)
XM_006713387.2 → XP_006713450.1 leucine-rich repeat flightless-interacting protein 2 isoform X3

Conserved Domains (1) summary

pfam09738
Location:277 → 631

DUF2051; Double stranded RNA binding protein (DUF2051)
XM_006713397.2 → XP_006713460.1 leucine-rich repeat flightless-interacting protein 2 isoform X13

Conserved Domains (1) summary

pfam09738
Location:218 → 574

DUF2051; Double stranded RNA binding protein (DUF2051)
XM_047449203.1 → XP_047305159.1 leucine-rich repeat flightless-interacting protein 2 isoform X16
XM_006713393.2 → XP_006713456.1 leucine-rich repeat flightless-interacting protein 2 isoform X7

Conserved Domains (1) summary

pfam09738
Location:262 → 616

DUF2051; Double stranded RNA binding protein (DUF2051)
XM_017007469.2 → XP_016862958.1 leucine-rich repeat flightless-interacting protein 2 isoform X15
XM_017007467.2 → XP_016862956.1 leucine-rich repeat flightless-interacting protein 2 isoform X10
XM_006713392.2 → XP_006713455.1 leucine-rich repeat flightless-interacting protein 2 isoform X6

Conserved Domains (2) summary

pfam09738
Location:292 → 622

DUF2051; Double stranded RNA binding protein (DUF2051)

pfam13870
Location:398 → 495

DUF4201; Domain of unknown function (DUF4201)
XM_011534222.2 → XP_011532524.1 leucine-rich repeat flightless-interacting protein 2 isoform X12

Conserved Domains (2) summary

pfam09738
Location:292 → 581

DUF2051; Double stranded RNA binding protein (DUF2051)

pfam17031
Location:348 → 404

DUF5101; Domain of unknown function (DUF5101)
XM_006713395.2 → XP_006713458.1 leucine-rich repeat flightless-interacting protein 2 isoform X8

Conserved Domains (3) summary

pfam09738
Location:292 → 615

DUF2051; Double stranded RNA binding protein (DUF2051)

cd16269
Location:462 → 475

GBP_C; coiled coil [structural motif]

cl20817
Location:342 → 482

GBP_C; Guanylate-binding protein, C-terminal domain
XM_011534217.2 → XP_011532519.1 leucine-rich repeat flightless-interacting protein 2 isoform X1

See identical proteins and their annotated locations for XP_011532519.1

UniProtKB/Swiss-Prot

A8K649, A8MXR0, B4DY63, Q68CV3, Q9NXH5, Q9Y608

Conserved Domains (2) summary

pfam09738
Location:292 → 646

LRRFIP; LRRFIP family

pfam11932
Location:662 → 721

DUF3450; Protein of unknown function (DUF3450)
XM_017007476.2 → XP_016862965.1 leucine-rich repeat flightless-interacting protein 2 isoform X22

Conserved Domains (2) summary

pfam09738
Location:47 → 414

LRRFIP; LRRFIP family

cl25732
Location:187 → 488

SMC_N; RecF/RecN/SMC N terminal domain
XM_047449205.1 → XP_047305161.1 leucine-rich repeat flightless-interacting protein 2 isoform X21
XM_047449207.1 → XP_047305163.1 leucine-rich repeat flightless-interacting protein 2 isoform X24
XM_006713390.2 → XP_006713453.1 leucine-rich repeat flightless-interacting protein 2 isoform X5

See identical proteins and their annotated locations for XP_006713453.1

Conserved Domains (3) summary

pfam04111
Location:609 → 704

APG6; Autophagy protein Apg6

pfam04156
Location:382 → 505

IncA; IncA protein

pfam09738
Location:275 → 629

LRRFIP; LRRFIP family
XM_011534218.2 → XP_011532520.1 leucine-rich repeat flightless-interacting protein 2 isoform X1

See identical proteins and their annotated locations for XP_011532520.1

UniProtKB/Swiss-Prot

A8K649, A8MXR0, B4DY63, Q68CV3, Q9NXH5, Q9Y608

Conserved Domains (2) summary

pfam09738
Location:292 → 646

LRRFIP; LRRFIP family

pfam11932
Location:662 → 721

DUF3450; Protein of unknown function (DUF3450)
XM_011534219.2 → XP_011532521.1 leucine-rich repeat flightless-interacting protein 2 isoform X1

See identical proteins and their annotated locations for XP_011532521.1

UniProtKB/Swiss-Prot

A8K649, A8MXR0, B4DY63, Q68CV3, Q9NXH5, Q9Y608

Conserved Domains (2) summary

pfam09738
Location:292 → 646

LRRFIP; LRRFIP family

pfam11932
Location:662 → 721

DUF3450; Protein of unknown function (DUF3450)
XM_024453824.2 → XP_024309592.1 leucine-rich repeat flightless-interacting protein 2 isoform X23

Conserved Domains (2) summary

pfam04111
Location:370 → 465

APG6; Autophagy protein Apg6

pfam09738
Location:47 → 390

LRRFIP; LRRFIP family
XM_047449208.1 → XP_047305164.1 leucine-rich repeat flightless-interacting protein 2 isoform X25

UniProtKB/TrEMBL

A0A1S5UZ17
XM_047449206.1 → XP_047305162.1 leucine-rich repeat flightless-interacting protein 2 isoform X24
XM_024453821.2 → XP_024309589.1 leucine-rich repeat flightless-interacting protein 2 isoform X11

Conserved Domains (3) summary

pfam04111
Location:563 → 658

APG6; Autophagy protein Apg6

pfam04156
Location:336 → 459

IncA; IncA protein

pfam09738
Location:229 → 583

LRRFIP; LRRFIP family
XM_024453820.2 → XP_024309588.1 leucine-rich repeat flightless-interacting protein 2 isoform X5

Conserved Domains (3) summary

pfam04111
Location:609 → 704

APG6; Autophagy protein Apg6

pfam04156
Location:382 → 505

IncA; IncA protein

pfam09738
Location:275 → 629

LRRFIP; LRRFIP family
XM_005265539.3 → XP_005265596.1 leucine-rich repeat flightless-interacting protein 2 isoform X1

See identical proteins and their annotated locations for XP_005265596.1

UniProtKB/Swiss-Prot

A8K649, A8MXR0, B4DY63, Q68CV3, Q9NXH5, Q9Y608

Conserved Domains (2) summary

pfam09738
Location:292 → 646

LRRFIP; LRRFIP family

pfam11932
Location:662 → 721

DUF3450; Protein of unknown function (DUF3450)
XM_005265540.2 → XP_005265597.1 leucine-rich repeat flightless-interacting protein 2 isoform X1

See identical proteins and their annotated locations for XP_005265597.1

UniProtKB/Swiss-Prot

A8K649, A8MXR0, B4DY63, Q68CV3, Q9NXH5, Q9Y608

Conserved Domains (2) summary

pfam09738
Location:292 → 646

LRRFIP; LRRFIP family

pfam11932
Location:662 → 721

DUF3450; Protein of unknown function (DUF3450)
XM_047449201.1 → XP_047305157.1 leucine-rich repeat flightless-interacting protein 2 isoform X1

UniProtKB/Swiss-Prot

A8K649, A8MXR0, B4DY63, Q68CV3, Q9NXH5, Q9Y608

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

37053969..37177703 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054348390.1 → XP_054204365.1 leucine-rich repeat flightless-interacting protein 2 isoform X9
XM_054348409.1 → XP_054204384.1 leucine-rich repeat flightless-interacting protein 2 isoform X25

UniProtKB/TrEMBL

A0A1S5UZ17
XM_054348403.1 → XP_054204378.1 leucine-rich repeat flightless-interacting protein 2 isoform X21
XM_054348406.1 → XP_054204381.1 leucine-rich repeat flightless-interacting protein 2 isoform X24
XM_054348400.1 → XP_054204375.1 leucine-rich repeat flightless-interacting protein 2 isoform X19
XM_054348398.1 → XP_054204373.1 leucine-rich repeat flightless-interacting protein 2 isoform X17
XM_054348384.1 → XP_054204359.1 leucine-rich repeat flightless-interacting protein 2 isoform X5
XM_054348401.1 → XP_054204376.1 leucine-rich repeat flightless-interacting protein 2 isoform X20
XM_054348399.1 → XP_054204374.1 leucine-rich repeat flightless-interacting protein 2 isoform X18
XM_054348395.1 → XP_054204370.1 leucine-rich repeat flightless-interacting protein 2 isoform X14
XM_054348383.1 → XP_054204358.1 leucine-rich repeat flightless-interacting protein 2 isoform X4
XM_054348381.1 → XP_054204356.1 leucine-rich repeat flightless-interacting protein 2 isoform X2
XM_054348382.1 → XP_054204357.1 leucine-rich repeat flightless-interacting protein 2 isoform X3
XM_054348394.1 → XP_054204369.1 leucine-rich repeat flightless-interacting protein 2 isoform X13
XM_054348397.1 → XP_054204372.1 leucine-rich repeat flightless-interacting protein 2 isoform X16
XM_054348388.1 → XP_054204363.1 leucine-rich repeat flightless-interacting protein 2 isoform X7
XM_054348396.1 → XP_054204371.1 leucine-rich repeat flightless-interacting protein 2 isoform X15
XM_054348391.1 → XP_054204366.1 leucine-rich repeat flightless-interacting protein 2 isoform X10
XM_054348387.1 → XP_054204362.1 leucine-rich repeat flightless-interacting protein 2 isoform X6
XM_054348393.1 → XP_054204368.1 leucine-rich repeat flightless-interacting protein 2 isoform X12
XM_054348389.1 → XP_054204364.1 leucine-rich repeat flightless-interacting protein 2 isoform X8
XM_054348375.1 → XP_054204350.1 leucine-rich repeat flightless-interacting protein 2 isoform X1
XM_054348404.1 → XP_054204379.1 leucine-rich repeat flightless-interacting protein 2 isoform X22
XM_054348402.1 → XP_054204377.1 leucine-rich repeat flightless-interacting protein 2 isoform X21
XM_054348408.1 → XP_054204383.1 leucine-rich repeat flightless-interacting protein 2 isoform X24
XM_054348386.1 → XP_054204361.1 leucine-rich repeat flightless-interacting protein 2 isoform X5
XM_054348377.1 → XP_054204352.1 leucine-rich repeat flightless-interacting protein 2 isoform X1
XM_054348379.1 → XP_054204354.1 leucine-rich repeat flightless-interacting protein 2 isoform X1
XM_054348405.1 → XP_054204380.1 leucine-rich repeat flightless-interacting protein 2 isoform X23
XM_054348410.1 → XP_054204385.1 leucine-rich repeat flightless-interacting protein 2 isoform X25

UniProtKB/TrEMBL

A0A1S5UZ17
XM_054348407.1 → XP_054204382.1 leucine-rich repeat flightless-interacting protein 2 isoform X24
XM_054348392.1 → XP_054204367.1 leucine-rich repeat flightless-interacting protein 2 isoform X11
XM_054348385.1 → XP_054204360.1 leucine-rich repeat flightless-interacting protein 2 isoform X5
XM_054348376.1 → XP_054204351.1 leucine-rich repeat flightless-interacting protein 2 isoform X1
XM_054348378.1 → XP_054204353.1 leucine-rich repeat flightless-interacting protein 2 isoform X1
XM_054348380.1 → XP_054204355.1 leucine-rich repeat flightless-interacting protein 2 isoform X1