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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_008959.1 RefSeqGene
- Range
-
5012..113701
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_000254.3 → NP_000245.2 methionine synthase isoform 1
See identical proteins and their annotated locations for NP_000245.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
- Source sequence(s)
-
AL359185, AL359259
- Consensus CDS
-
CCDS1614.1
- UniProtKB/Swiss-Prot
- A1L4N8, A9Z1W4, B7ZLW7, B9EGF7, Q99707, Q99713, Q99723
- UniProtKB/TrEMBL
-
B7ZLW8
- Related
- ENSP00000355536.5, ENST00000366577.10
- Conserved Domains (5) summary
-
- COG0646
Location:21 → 340
- MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
- PRK09490
Location:19 → 1261
- metH; B12-dependent methionine synthase; Provisional
- cd00740
Location:371 → 627
- MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
- cd02069
Location:671 → 897
- methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
- pfam02965
Location:965 → 1246
- Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain
-
NM_001291939.1 → NP_001278868.1 methionine synthase isoform 2
See identical proteins and their annotated locations for NP_001278868.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
- Source sequence(s)
-
AL359259, BC144095, CB241165, DC377743
- Consensus CDS
-
CCDS73054.1
- UniProtKB/TrEMBL
-
B7ZLW8
- Related
- ENSP00000441845.1, ENST00000535889.6
- Conserved Domains (5) summary
-
- COG0646
Location:21 → 340
- MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
- PRK09490
Location:19 → 1210
- metH; B12-dependent methionine synthase; Provisional
- cd00740
Location:371 → 627
- MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
- pfam02965
Location:914 → 1195
- Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain
- cl00293
Location:679 → 846
- B12-binding_like; B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase, ...
-
NM_001291940.2 → NP_001278869.1 methionine synthase isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks an internal exon, which causes translation initiation at a downstream AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
- Source sequence(s)
-
AL359259, BC136440, BC144098, CB241165, DC377743
- UniProtKB/TrEMBL
-
B1ANE3
- Conserved Domains (4) summary
-
- COG1410
Location:2 → 823
- MetH2; Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]
- cd00740
Location:1 → 220
- MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
- cd02069
Location:264 → 490
- methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
- pfam02965
Location:558 → 839
- Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain
-
NM_001410942.1 → NP_001397871.1 methionine synthase isoform 4
Status: REVIEWED
- Source sequence(s)
-
AL359185, AL359259
- Consensus CDS
-
CCDS91175.1
- UniProtKB/TrEMBL
- A0A7P0TAJ0, B7ZLW8
- Related
- ENSP00000506109.1, ENST00000679842.1
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000001.11 Reference GRCh38.p14 Primary Assembly
- Range
-
236795281..236903981
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047421186.1 → XP_047277142.1 methionine synthase isoform X8
- UniProtKB/TrEMBL
-
B7ZLW8
-
XM_005273141.6 → XP_005273198.1 methionine synthase isoform X3
- UniProtKB/TrEMBL
-
B7ZLW8
- Conserved Domains (5) summary
-
- COG0646
Location:20 → 339
- MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
- PRK09490
Location:18 → 1260
- metH; B12-dependent methionine synthase; Provisional
- cd00740
Location:370 → 626
- MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
- cd02069
Location:670 → 896
- methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
- pfam02965
Location:964 → 1245
- Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain
-
XM_047421185.1 → XP_047277141.1 methionine synthase isoform X7
- UniProtKB/TrEMBL
-
B7ZLW8
-
XM_047421182.1 → XP_047277138.1 methionine synthase isoform X5
- UniProtKB/TrEMBL
-
B7ZLW8
-
XM_011544194.4 → XP_011542496.1 methionine synthase isoform X1
- UniProtKB/TrEMBL
-
A0A6Q8PGK3
- Related
- ENSP00000502299.2, ENST00000674797.2
- Conserved Domains (5) summary
-
- COG0646
Location:140 → 396
- MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
- PRK09490
Location:140 → 1317
- metH; B12-dependent methionine synthase; Provisional
- cd00740
Location:427 → 683
- MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
- cd02069
Location:727 → 953
- methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
- pfam02965
Location:1021 → 1302
- Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain
-
XM_017001330.3 → XP_016856819.1 methionine synthase isoform X4
- UniProtKB/TrEMBL
-
A0A6Q8PGK3
-
XM_017001329.3 → XP_016856818.1 methionine synthase isoform X2
- UniProtKB/TrEMBL
-
A0A6Q8PGK3
-
XM_047421183.1 → XP_047277139.1 methionine synthase isoform X6
- UniProtKB/TrEMBL
-
A0A6Q8PGK3
-
XM_047421187.1 → XP_047277143.1 methionine synthase isoform X9
- UniProtKB/TrEMBL
-
B1ANE3
- Related
- ENSP00000355535.3, ENST00000366576.3
Alternate T2T-CHM13v2.0
Genomic
-
NC_060925.1 Alternate T2T-CHM13v2.0
- Range
-
236206330..236315021
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054336715.1 → XP_054192690.1 methionine synthase isoform X8
- UniProtKB/TrEMBL
-
B7ZLW8
-
XM_054336710.1 → XP_054192685.1 methionine synthase isoform X3
- UniProtKB/TrEMBL
-
B7ZLW8
-
XM_054336714.1 → XP_054192689.1 methionine synthase isoform X7
- UniProtKB/TrEMBL
-
B7ZLW8
-
XM_054336712.1 → XP_054192687.1 methionine synthase isoform X5
- UniProtKB/TrEMBL
-
B7ZLW8
-
XM_054336708.1 → XP_054192683.1 methionine synthase isoform X1
- UniProtKB/TrEMBL
-
A0A6Q8PGK3
-
XM_054336711.1 → XP_054192686.1 methionine synthase isoform X4
- UniProtKB/TrEMBL
-
A0A6Q8PGK3
-
XM_054336709.1 → XP_054192684.1 methionine synthase isoform X2
- UniProtKB/TrEMBL
-
A0A6Q8PGK3
-
XM_054336713.1 → XP_054192688.1 methionine synthase isoform X6
- UniProtKB/TrEMBL
-
A0A6Q8PGK3
-
XM_054336716.1 → XP_054192691.1 methionine synthase isoform X9
- UniProtKB/TrEMBL
-
B1ANE3