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    TXNL1 thioredoxin like 1 [ Homo sapiens (human) ]

    Gene ID: 9352, updated on 9-Dec-2024

    Summary

    Official Symbol
    TXNL1provided by HGNC
    Official Full Name
    thioredoxin like 1provided by HGNC
    Primary source
    HGNC:HGNC:12436
    See related
    Ensembl:ENSG00000091164 MIM:603049; AllianceGenome:HGNC:12436
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Txl; TXNL; TRP32; TXL-1; HEL-S-114
    Summary
    Enables disulfide oxidoreductase activity. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 57.8), testis (RPKM 14.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TXNL1 in Genome Data Viewer
    Location:
    18q21.31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (56597209..56638592, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (56799245..56840564, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (54264440..54305823, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 3069 Neighboring gene uncharacterized LOC105372132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13361 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13362 Neighboring gene NANOG hESC enhancer GRCh37_chr18:54019108-54019609 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:54080945-54081494 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:54087957-54088683 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:54230563-54231064 Neighboring gene uncharacterized LOC105372135 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:54304875-54305860 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:54305861-54306845 Neighboring gene Sharpr-MPRA regulatory region 10710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13364 Neighboring gene WD repeat domain 7 Neighboring gene NANOG hESC enhancer GRCh37_chr18:54503488-54503989 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:54540953-54541541 Neighboring gene uncharacterized LOC124904382 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:54653903-54654752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:54679651-54680151 Neighboring gene WDR7 overlapping transcript 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables disulfide oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    thioredoxin-like protein 1
    Names
    32 kDa thioredoxin-related protein
    epididymis secretory protein Li 114
    thioredoxin-related 32 kDa protein
    thioredoxin-related protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004786.3NP_004777.1  thioredoxin-like protein 1

      See identical proteins and their annotated locations for NP_004777.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein coding transcript.
      Source sequence(s)
      AC007052, AF003938, AV750604
      Consensus CDS
      CCDS11961.1
      UniProtKB/Swiss-Prot
      O43396
      UniProtKB/TrEMBL
      B2R960, V9HW51
      Related
      ENSP00000217515.5, ENST00000217515.11
      Conserved Domains (2) summary
      cd02947
      Location:12104
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      pfam06201
      Location:128268
      PITH; PITH domain

    RNA

    1. NR_024546.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an additional exon compared to transcript variant 1. This results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense mediated mRNA decay (NMD). This transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because it is significantly truncated.
      Source sequence(s)
      AC007052, AF003938, AV750604, DA248363

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      56597209..56638592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451289.2XP_024307057.1  thioredoxin-like protein 1 isoform X1

      UniProtKB/TrEMBL
      B2R960
      Conserved Domains (2) summary
      cd02947
      Location:12104
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      pfam06201
      Location:128268
      PITH; PITH domain
    2. XM_024451290.2XP_024307058.1  thioredoxin-like protein 1 isoform X2

      UniProtKB/TrEMBL
      B2R960
      Related
      ENSP00000468165.1, ENST00000586262.5
      Conserved Domains (2) summary
      cd02947
      Location:12104
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      pfam06201
      Location:128268
      PITH; PITH domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      56799245..56840564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)