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    SVOP SV2 related protein [ Homo sapiens (human) ]

    Gene ID: 55530, updated on 27-Nov-2024

    Summary

    Official Symbol
    SVOPprovided by HGNC
    Official Full Name
    SV2 related proteinprovided by HGNC
    Primary source
    HGNC:HGNC:25417
    See related
    Ensembl:ENSG00000166111 MIM:611699; AllianceGenome:HGNC:25417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLC22B4
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport and xenobiotic transport. Predicted to be located in synaptic vesicle. Predicted to be active in synaptic vesicle membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 14.1) and adrenal (RPKM 0.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    12q24.11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (108907741..109021068, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (108882524..108995882, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109301517..109458873, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene slingshot protein phosphatase 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:109231638-109232837 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109232831-109233432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4836 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:109247741-109248940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109250055-109250556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4837 Neighboring gene microRNA 619 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:109273628-109274245 Neighboring gene MPRA-validated peak1937 silencer Neighboring gene uncharacterized LOC124903011 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:109300977-109301477 Neighboring gene NANOG hESC enhancer GRCh37_chr12:109311835-109312350 Neighboring gene D-amino acid oxidase Neighboring gene RNA, U6 small nuclear 361, pseudogene Neighboring gene uncharacterized LOC105378256 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:109490575-109491074 Neighboring gene ubiquitin specific peptidase 30 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6983 Neighboring gene USP30 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 372

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp761H039

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    synaptic vesicle 2-related protein
    Names
    SV2 related protein homolog
    solute carrier family 22 member B4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018711.5NP_061181.1  synaptic vesicle 2-related protein

      See identical proteins and their annotated locations for NP_061181.1

      Status: VALIDATED

      Source sequence(s)
      AC087893, BC033587, BC037811, BC094722, DA793417, DB297770
      Consensus CDS
      CCDS73520.1
      UniProtKB/Swiss-Prot
      Q8N4V2, Q9NPW5
      Related
      ENSP00000479104.1, ENST00000610966.5
      Conserved Domains (1) summary
      cd17441
      Location:87509
      MFS_SVOP; Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      108907741..109021068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      108882524..108995882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)