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    SPRY3 sprouty RTK signaling antagonist 3 [ Homo sapiens (human) ]

    Gene ID: 10251, updated on 9-Dec-2024

    Summary

    Official Symbol
    SPRY3provided by HGNC
    Official Full Name
    sprouty RTK signaling antagonist 3provided by HGNC
    Primary source
    HGNC:HGNC:11271
    See related
    Ensembl:ENSG00000168939 MIM:300531; AllianceGenome:HGNC:11271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    spry-3
    Summary
    Involved in negative regulation of MAPK cascade. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SPRY3 in Genome Data Viewer
    Location:
    Xq28 and Yq12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (155612586..155782459)
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (56923423..56968979)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (153837809..154007734)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (62159112..62204700)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (154842247..155012121)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (59069571..59115127)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene int22h-3 recombination region Neighboring gene TMLHE antisense RNA 1 Neighboring gene H2A.B variant histone 3 Neighboring gene trimethyllysine hydroxylase, epsilon Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30078 Neighboring gene meiotic recombination hotspot PAR2A Neighboring gene meiotic recombination hotspot PAR2 Neighboring gene adenosylmethionine decarboxylase 1 pseudogene 2 Neighboring gene diphthamide biosynthesis 3 pseudogene 2

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:28797811-28798580 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:28798753-28799442 Neighboring gene poly(ADP-ribose) polymerase family member 4 pseudogene 1 Neighboring gene CCNQ pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrY:58981135-58981878 Neighboring gene meiotic recombination hotspot PAR2 Neighboring gene meiotic recombination hotspot PAR2A Neighboring gene H3K27ac hESC enhancer GRCh37_chrY:58996593-58997092 Neighboring gene OCT4 hESC enhancer GRCh37_chrY:58993067-58993568 Neighboring gene OCT4 hESC enhancer GRCh37_chrY:58991323-58991865 Neighboring gene OCT4 hESC enhancer GRCh37_chrY:58988210-58988711 Neighboring gene OCT4 hESC enhancer GRCh37_chrY:58987057-58987801 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58985458-58986055 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58982623-58983366 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58981879-58982622 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:58979645-58980388 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrY:58978901-58979644 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrY:58978157-58978900 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrY:58977411-58978156 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58976667-58977410 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58975923-58976666 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrY:58975179-58975922 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58971453-58972198 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58861881-58862424 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58862425-58862968 Neighboring gene CTBP2 pseudogene 1 Neighboring gene adenosylmethionine decarboxylase 1 pseudogene 2 Neighboring gene diphthamide biosynthesis 3 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of neuron projection arborization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein sprouty homolog 3
    Names
    antagonist of FGF signaling
    sprouty homolog 3
    sprouty3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304990.2NP_001291919.1  protein sprouty homolog 3

      See identical proteins and their annotated locations for NP_001291919.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. This variant is only expected to be expressed from the X chromosome. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AJ271735, BX323057, KC877980, KC877984, KC877988, KC877989, KF495814
      Consensus CDS
      CCDS14769.4
      UniProtKB/Swiss-Prot
      A8K0H8, O43610
      Related
      ENSP00000511806.1, ENST00000695325.1
      Conserved Domains (1) summary
      pfam05210
      Location:152253
      Sprouty; Sprouty protein (Spry)
    2. NM_001394353.1NP_001381282.1  protein sprouty homolog 3

      Status: VALIDATED

      Source sequence(s)
      AJ271735, BX323057, KC877980, KC877984, KC877988, KC877989, KF495814
      Consensus CDS
      CCDS14769.4
      UniProtKB/Swiss-Prot
      A8K0H8, O43610
      Related
      ENSP00000502489.1, ENST00000675360.1
      Conserved Domains (1) summary
      pfam05210
      Location:152253
      Sprouty; Sprouty protein (Spry)
    3. NM_001394354.1NP_001381283.1  protein sprouty homolog 3

      Status: VALIDATED

      Source sequence(s)
      AJ271735, BX323057, KC877980, KC877984, KC877988, KC877989, KF495814
      Consensus CDS
      CCDS14769.4
      UniProtKB/Swiss-Prot
      A8K0H8, O43610
      Conserved Domains (1) summary
      pfam05210
      Location:152253
      Sprouty; Sprouty protein (Spry)
    4. NM_001394355.1NP_001381284.1  protein sprouty homolog 3

      Status: VALIDATED

      Source sequence(s)
      AJ271735, BX323057, KC877980, KC877984, KC877988, KC877989, KF495814
      Consensus CDS
      CCDS14769.4
      UniProtKB/Swiss-Prot
      A8K0H8, O43610
      Conserved Domains (1) summary
      pfam05210
      Location:152253
      Sprouty; Sprouty protein (Spry)
    5. NM_005840.4NP_005831.1  protein sprouty homolog 3

      See identical proteins and their annotated locations for NP_005831.1

      Status: VALIDATED

      Source sequence(s)
      AJ271735, KC877980, KC877984, KC877988, KC877989, KF495814
      Consensus CDS
      CCDS14769.4
      UniProtKB/Swiss-Prot
      A8K0H8, O43610
      Related
      ENSP00000302978.2, ENST00000302805.7
      Conserved Domains (1) summary
      pfam05210
      Location:152253
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      155612586..155782459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      56923423..56968979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      153837809..154007734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      62159112..62204700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)