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    AIDA axin interactor, dorsalization associated [ Homo sapiens (human) ]

    Gene ID: 64853, updated on 9-Dec-2024

    Summary

    Official Symbol
    AIDAprovided by HGNC
    Official Full Name
    axin interactor, dorsalization associatedprovided by HGNC
    Primary source
    HGNC:HGNC:25761
    See related
    Ensembl:ENSG00000186063 MIM:612375; AllianceGenome:HGNC:25761
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C1orf80
    Summary
    Predicted to enable phosphatidylinositol binding activity. Acts upstream of or within negative regulation of JUN kinase activity. Predicted to be located in cytoplasm. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in fat (RPKM 42.6), testis (RPKM 31.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See AIDA in Genome Data Viewer
    Location:
    1q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (222668013..222712491, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (221901757..221946247, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (222841355..222885833, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor, RNA polymerase I subunit A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:222763242-222763775 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:222763776-222764308 Neighboring gene TAF1A antisense RNA 1 Neighboring gene H3K27me3-DHS negatively-acting regulatory element H1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:222791257-222792139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2577 Neighboring gene MIA SH3 domain ER export factor 3 Neighboring gene prefoldin subunit 5-like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:222816645-222817522 and GRCh37_chr1:222817523-222818398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2581 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5183 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:222885601-222886515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5205 Neighboring gene BRO1 domain and CAAX motif containing Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:222909786-222910327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1836 Neighboring gene family with sequence similarity 177 member B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12806, FLJ32421

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in determination of ventral identity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dorsal/ventral pattern formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    axin interactor, dorsalization-associated protein
    Names
    axin interaction partner and dorsalization antagonist

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022831.4NP_073742.2  axin interactor, dorsalization-associated protein

      See identical proteins and their annotated locations for NP_073742.2

      Status: VALIDATED

      Source sequence(s)
      AL392172, AL592148
      Consensus CDS
      CCDS1533.1
      UniProtKB/Swiss-Prot
      A8K1F0, Q49A81, Q5JRA4, Q658P1, Q96BJ3, Q9H9E8
      UniProtKB/TrEMBL
      B7ZW30
      Related
      ENSP00000339161.6, ENST00000340020.11
      Conserved Domains (2) summary
      pfam08910
      Location:9112
      Aida_N; Aida N-terminus
      pfam14186
      Location:162300
      Aida_C2; Cytoskeletal adhesion

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      222668013..222712491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428100.1XP_047284056.1  axin interactor, dorsalization-associated protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      221901757..221946247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338316.1XP_054194291.1  axin interactor, dorsalization-associated protein isoform X2

    2. XM_054338315.1XP_054194290.1  axin interactor, dorsalization-associated protein isoform X1