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    MIR491 microRNA 491 [ Homo sapiens (human) ]

    Gene ID: 574444, updated on 9-Dec-2024

    Summary

    Official Symbol
    MIR491provided by HGNC
    Official Full Name
    microRNA 491provided by HGNC
    Primary source
    HGNC:HGNC:32076
    See related
    Ensembl:ENSG00000207609 miRBase:MI0003126; AllianceGenome:HGNC:32076
    Gene type
    ncRNA
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIRN491; mir-491; hsa-mir-491
    Summary
    microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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    Genomic context

    See MIR491 in Genome Data Viewer
    Location:
    9p21.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (20716105..20716188)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (20729892..20729975)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (20716104..20716187)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene MLLT3 super elongation complex subunit Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28227 Neighboring gene ribosomal protein L7a pseudogene 48 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19801 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28230 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:20683960-20684700 Neighboring gene FOCAD antisense RNA 1 Neighboring gene focadhesin Neighboring gene small nucleolar RNA, H/ACA box 30B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19803 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:21031418-21031978 Neighboring gene 3-hydroxyacyl-CoA dehydratase 4

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_030166.1 RNA Sequence

      Status: PROVISIONAL

      Source sequence(s)
      AL445624
      Related
      ENST00000384877.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      20716105..20716188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      20729892..20729975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)