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    Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 [ Mus musculus (house mouse) ]

    Gene ID: 68262, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Agpat4provided by MGI
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase 4provided by MGI
    Primary source
    MGI:MGI:1915512
    See related
    Ensembl:ENSMUSG00000023827 AllianceGenome:MGI:1915512
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500003P24Rik
    Summary
    Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in phospholipid metabolic process. Located in endoplasmic reticulum. Is active in mitochondrial outer membrane. Is expressed in several structures, including nervous system; skin; stomach; and testis. Orthologous to human AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 23.0), lung adult (RPKM 13.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Agpat4 in Genome Data Viewer
    Location:
    17 A1; 17 8.33 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (12337372..12438536)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12118485..12219649)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene parkin RBR E3 ubiquitin protein ligase Neighboring gene STARR-seq mESC enhancer starr_41839 Neighboring gene DNA segment, Chr 17, ERATO Doi 648, expressed Neighboring gene STARR-seq mESC enhancer starr_41840 Neighboring gene STARR-seq mESC enhancer starr_41841 Neighboring gene predicted gene, 46604 Neighboring gene STARR-seq mESC enhancer starr_41845 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:12311592-12311701 Neighboring gene STARR-seq mESC enhancer starr_41846 Neighboring gene STARR-positive B cell enhancer ABC_E4192 Neighboring gene STARR-seq mESC enhancer starr_41847 Neighboring gene STARR-seq mESC enhancer starr_41848 Neighboring gene VISTA enhancer mm156 Neighboring gene STARR-positive B cell enhancer mm9_chr17:12398581-12398882 Neighboring gene teratocarcinoma-derived growth factor, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_41854 Neighboring gene mitogen-activated protein kinase kinase kinase 4 Neighboring gene predicted gene, 46605 Neighboring gene predicted gene, 24794

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lpaatδ/Agpat4 deficiency impairs maximal force contractility in soleus and alters fibre type in extensor digitorum longus muscle. Bradley RM, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Jul. PMID 29627383
    2. Agpat4/Lpaatδ deficiency highlights the molecular heterogeneity of epididymal and perirenal white adipose depots. Mardian EB, et al. J Lipid Res, 2017 Oct. PMID 28814640, Free PMC Article
    3. Mice Deficient in lysophosphatidic acid acyltransferase delta (Lpaatδ)/acylglycerophosphate acyltransferase 4 (Agpat4) Have Impaired Learning and Memory. Bradley RM, et al. Mol Cell Biol, 2017 Nov 15. PMID 28807933, Free PMC Article
    4. Data on acylglycerophosphate acyltransferase 4 (AGPAT4) during murine embryogenesis and in embryo-derived cultured primary neurons and glia. Bradley RM, et al. Data Brief, 2016 Mar. PMID 26759825, Free PMC Article
    5. A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids. Eto M, et al. Biochem Biophys Res Commun, 2014 Jan 10. PMID 24333445

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study utilizing Lpaat-delta deficient mice identify an important role for murine Lpaat-delta in musculus soleus and extensor digitorum longus contractile force generation.
      Title: Lpaatδ/Agpat4 deficiency impairs maximal force contractility in soleus and alters fibre type in extensor digitorum longus muscle.
    2. Agpat4/Lpaatdelta deficiency highlights the molecular heterogeneity of epididymal and perirenal white adipose depots
      Title: Agpat4/Lpaatδ deficiency highlights the molecular heterogeneity of epididymal and perirenal white adipose depots.
    3. Findings indicate that Lpaatdelta deficiency causes deficits in learning and memory associated with reduced NMDA and AMPA receptors.
      Title: Mice Deficient in lysophosphatidic acid acyltransferase delta (Lpaatδ)/acylglycerophosphate acyltransferase 4 (Agpat4) Have Impaired Learning and Memory.
    4. findings indicate that AGPAT4 is a mitochondrial AGPAT/LPAAT that specifically supports synthesis of brain PI, PC, and PE.
      Title: Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophosphatidic acid acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-acyl-sn-glycerol-3-phosphate acyltransferase delta
    Names
    1-AGP acyltransferase 4
    1-AGPAT 4
    1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, delta)
    1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
    LPAAT-delta
    lysophosphatidic acid acyltransferase-delta
    NP_080920.2
    XP_006523408.3
    XP_006523410.1
    XP_006523411.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026644.2 → NP_080920.2  1-acyl-sn-glycerol-3-phosphate acyltransferase delta

      See identical proteins and their annotated locations for NP_080920.2

      Status: PROVISIONAL

      Source sequence(s)
      AK005139
      Consensus CDS
      CCDS28389.1
      UniProtKB/Swiss-Prot
      Q3TKN0, Q8K4X7, Q9DB84
      Related
      ENSMUSP00000024594.3, ENSMUST00000024594.9
      Conserved Domains (1) summary
      PLN02380
      Location:20 → 326
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      12337372..12438536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523347.3 → XP_006523410.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X2

      See identical proteins and their annotated locations for XP_006523410.1

      Conserved Domains (2) summary
      cd07990
      Location:11 → 150
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:136 → 208
      Acyltransf_C; Acyltransferase C-terminus

    2. XM_006523345.3 → XP_006523408.3  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1

      Conserved Domains (1) summary
      PLN02380
      Location:100 → 406
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

    3. XM_006523348.5 → XP_006523411.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X2

      See identical proteins and their annotated locations for XP_006523411.1

      Conserved Domains (2) summary
      cd07990
      Location:11 → 150
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:136 → 208
      Acyltransf_C; Acyltransferase C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4X7.1 GenPept UniProtKB/Swiss-Prot:Q8K4X7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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