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    IL10RB interleukin 10 receptor subunit beta [ Homo sapiens (human) ]

    Gene ID: 3588, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IL10RBprovided by HGNC
    Official Full Name
    interleukin 10 receptor subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:5965
    See related
    Ensembl:ENSG00000243646 MIM:123889; AllianceGenome:HGNC:5965
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRFB4; IBD25; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2; IL-10RB
    Summary
    The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
    Expression
    Ubiquitous expression in placenta (RPKM 32.9), colon (RPKM 23.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IL10RB in Genome Data Viewer
    Location:
    21q22.11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (33266367..33310182)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (31635162..31678970)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34638672..34682487)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372787 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13249 Neighboring gene IFNAR2-IL10RB readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18370 Neighboring gene NANOG hESC enhancer GRCh37_chr21:34617736-34618335 Neighboring gene interferon alpha and beta receptor subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18373 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18374 Neighboring gene IL10RB divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18375 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:34676441-34676940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13255 Neighboring gene IFNAR1 promoter region Neighboring gene interferon alpha and beta receptor subunit 1 Neighboring gene upstream transcription factor 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 14728 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:34738709-34739908 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:34752348-34753547 Neighboring gene Sharpr-MPRA regulatory region 6397 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:34758349-34758554 Neighboring gene IFNGR2 promoter region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13257 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13259 Neighboring gene CRISPRi-FlowFISH-validated IFNGR2 regulatory element GRCh37_chr21:34776289-34777452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:34784507-34785261 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:34785395-34785563 Neighboring gene interferon gamma receptor 2 Neighboring gene transmembrane protein 50B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clinical and cellular phenotypes resulting from a founder mutation in IL10RB. Mao Z, et al. Clin Exp Immunol, 2024 Apr 23. PMID 37503744, Free PMC Article
    2. Structure of the human CRFB4 gene: comparison with its IFNAR neighbor. Lutfalla G, et al. J Mol Evol, 1995 Sep. PMID 7563119
    3. A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. Lutfalla G, et al. Genomics, 1993 May. PMID 8314576
    4. The influence of pro-inflammatory cytokines on human retinal pigment epithelium cell receptors. Hollborn M, et al. Graefes Arch Clin Exp Ophthalmol, 2001 Apr. PMID 11450494
    5. Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis. Hikami K, et al. Biochem Biophys Res Commun, 2008 Aug 29. PMID 18588853

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical and cellular phenotypes resulting from a founder mutation in IL10RB.
      Title: Clinical and cellular phenotypes resulting from a founder mutation in IL10RB.
    2. Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
      Title: Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
    3. Regulation of the Human IL-10RB Gene Expression by Sp8 and Sp9.
      Title: Regulation of the Human IL-10RB Gene Expression by Sp8 and Sp9.
    4. Association of Interleukin Genes IL10 and IL10RB with Parameters of Overweight in Military Students.
      Title: Association of Interleukin Genes IL10 and IL10RB with Parameters of Overweight in Military Students.
    5. Susceptibility to Heart Defects in Down Syndrome Is Associated with Single Nucleotide Polymorphisms in HAS 21 Interferon Receptor Cluster and VEGFA Genes.
      Title: Susceptibility to Heart Defects in Down Syndrome Is Associated with Single Nucleotide Polymorphisms in HAS 21 Interferon Receptor Cluster and VEGFA Genes.
    6. IL-10 receptor expression on lymphocytes and monocytes in children with food allergy.
      Title: IL-10 receptor expression on lymphocytes and monocytes in children with food allergy.
    7. Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19.
      Title: Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19.
    8. Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130.
      Title: Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130.
    9. analysis of two novel copy number variations in IL10RB, one with founder effect and one preserving cell surface expression but abolishing signaling
      Title: Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds.
    10. IFN-lambda4 suppressed HIV infection of macrophages. This IFN-lambda4-mediated HIV inhibition was compromised by the antibodies against IFN-lambda receptor complex, IFN-lambdaR1/IL-10R2.
      Title: IFN-λ4 inhibits HIV infection of macrophages through signalling of IFN-λR1/IL-10R2 receptor complex.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Hepatitis B virus, susceptibility to
    MedGen: C1864880 OMIM: 610424 GeneReviews: Not available
    		Compare labs
    Inflammatory bowel disease 25
    MedGen: C2675508 OMIM: 612567 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: IFNAR2

    Readthrough IFNAR2-IL10RB

    Readthrough gene: IFNAR2-IL10RB, Included gene: IFNAR2

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables coreceptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables interleukin-10 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to interleukin-10 receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to virus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in interleukin-10-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in type III interferon-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of interleukin-28 receptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-10 receptor subunit beta
    Names
    IL-10 receptor subunit beta
    IL-10R subunit 2
    IL-10R subunit beta
    cytokine receptor class-II CRF2-4
    cytokine receptor class-II member 4
    cytokine receptor family 2 member 4
    cytokine receptor family II, member 4
    interleukin 10 receptor, beta
    interleukin-10 receptor subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012089.1 RefSeqGene

      Range
      4994..35868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_152

    mRNA and Protein(s)

    1. NM_000628.5 → NP_000619.3  interleukin-10 receptor subunit beta isoform 1 precursor

      See identical proteins and their annotated locations for NP_000619.3

      Status: REVIEWED

      Source sequence(s)
      AI025402, AU133530, BC001903, Z17227
      Consensus CDS
      CCDS13623.1
      UniProtKB/Swiss-Prot
      Q08334, Q9BUU4
      UniProtKB/TrEMBL
      H2DF06
      Related
      ENSP00000290200.2, ENST00000290200.7
      Conserved Domains (2) summary
      pfam09294
      Location:111 → 213
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:21 → 100
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. NM_001405849.1 → NP_001392778.1  interleukin-10 receptor subunit beta isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000295
      UniProtKB/TrEMBL
      A0A1B0GTI5, B4DSX5
      Related
      ENSP00000489716.2, ENST00000637650.2

    3. NM_001405850.1 → NP_001392779.1  interleukin-10 receptor subunit beta isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000295
      UniProtKB/TrEMBL
      A0A1B0GU52, B4DSX5
      Related
      ENSP00000489965.2, ENST00000609556.3

    4. NM_001406840.1 → NP_001393769.1  interleukin-10 receptor subunit beta isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000295

    RNA

    1. NR_175973.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000295

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      33266367..33310182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      31635162..31678970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08334.2 GenPept UniProtKB/Swiss-Prot:Q08334

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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