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    OTUD6B-AS1 OTUD6B antisense RNA 1 (head to head) [ Homo sapiens (human) ]

    Gene ID: 100506365, updated on 10-Dec-2024

    Summary

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    Official Symbol
    OTUD6B-AS1provided by HGNC
    Official Full Name
    OTUD6B antisense RNA 1 (head to head)provided by HGNC
    Primary source
    HGNC:HGNC:50466
    See related
    Ensembl:ENSG00000253738 AllianceGenome:HGNC:50466
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GS1-251I9.4
    Expression
    Ubiquitous expression in thyroid (RPKM 8.2), brain (RPKM 7.9) and 25 other tissues See more
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    Genomic context

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    See OTUD6B-AS1 in Genome Data Viewer
    Location:
    8q21.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (91059906..91070189, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (92184831..92195114, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (92072134..92082417, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene N-terminal EF-hand calcium binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19354 Neighboring gene chromosome 8 open reading frame 88 Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27614 Neighboring gene OTU deubiquitinase 6B Neighboring gene MPRA-validated peak7106 silencer Neighboring gene leucine rich repeat containing 69 Neighboring gene ceruloplasmin pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability. Li PP, et al. Aging (Albany NY), 2021 Nov 5. PMID 34740994, Free PMC Article
    2. LncRNA OTUD6B-AS1 overexpression promoted GPX4-mediated ferroptosis to suppress radioresistance in colorectal cancer. Zhang Z, et al. Clin Transl Oncol, 2023 Nov. PMID 37184781
    3. OTUD6B-AS1 Might Be a Novel Regulator of Apoptosis in Systemic Sclerosis. Takata M, et al. Front Immunol, 2019. PMID 31156645, Free PMC Article
    4. OTUD6B-AS1 Inhibits Viability, Migration, and Invasion of Thyroid Carcinoma by Targeting miR-183-5p and miR-21. Wang Z, et al. Front Endocrinol (Lausanne), 2020. PMID 32256450, Free PMC Article
    5. Genome-wide meta-analysis identifies new susceptibility loci for migraine. Anttila V, et al. Nat Genet, 2013 Aug. PMID 23793025, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA OTUD6B-AS1 overexpression promoted GPX4-mediated ferroptosis to suppress radioresistance in colorectal cancer.
      Title: LncRNA OTUD6B-AS1 overexpression promoted GPX4-mediated ferroptosis to suppress radioresistance in colorectal cancer.
    2. LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability.
      Title: LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability.
    3. OTUD6B-AS1 Inhibits Viability, Migration, and Invasion of Thyroid Carcinoma by Targeting miR-183-5p and miR-21.
      Title: OTUD6B-AS1 Inhibits Viability, Migration, and Invasion of Thyroid Carcinoma by Targeting miR-183-5p and miR-21.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_110438.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC087439, BC030623, BM715864, CB242575
      Related
      ENST00000522817.3

    2. NR_110439.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' structure compared to variant 1.
      Source sequence(s)
      AC087439, BC105990
      Related
      ENST00000524003.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      91059906..91070189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      92184831..92195114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials