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    CREG2 cellular repressor of E1A stimulated genes 2 [ Homo sapiens (human) ]

    Gene ID: 200407, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CREG2provided by HGNC
    Official Full Name
    cellular repressor of E1A stimulated genes 2provided by HGNC
    Primary source
    HGNC:HGNC:14272
    See related
    Ensembl:ENSG00000175874 MIM:618540; AllianceGenome:HGNC:14272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward brain (RPKM 23.3) See more
    Orthologs
    mouse all
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    Genomic context

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    See CREG2 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101345550..101387503, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (101804250..101846207, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101962012..102003965, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ring finger protein 149 Neighboring gene uncharacterized LOC124906052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11825 Neighboring gene uncharacterized LOC105373512 Neighboring gene microRNA 5696 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:101946330-101947106 and GRCh37_chr2:101947107-101947883 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:101955361-101956145 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101986959-101987460 Neighboring gene succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11826 Neighboring gene regulatory factor X8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102075751-102076344 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:102080348-102081547 Neighboring gene NANOG hESC enhancer GRCh37_chr2:102083658-102084245 Neighboring gene long intergenic non-protein coding RNA 1870

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain. Kunita R, et al. Genomics, 2002 Nov. PMID 12408961
    2. USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c. Yao Y, et al. Oncogenesis, 2022 Jun 2. PMID 35654790, Free PMC Article
    3. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article
    4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CREG2 are putative secreted glycoproteins and may be novel neuronal extracellular molecules.
      Title: Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein CREG2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153836.4 → NP_722578.1  protein CREG2 precursor

      See identical proteins and their annotated locations for NP_722578.1

      Status: VALIDATED

      Source sequence(s)
      AB046109, AC099797
      Consensus CDS
      CCDS2052.1
      UniProtKB/Swiss-Prot
      Q86X03, Q8IUH2, Q8N540, Q8N9E3
      Related
      ENSP00000315203.4, ENST00000324768.6
      Conserved Domains (1) summary
      pfam13883
      Location:118 → 284
      Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      101345550..101387503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510777.3 → XP_011509079.2  protein CREG2 isoform X2

      UniProtKB/TrEMBL
      Q580X0

    2. XM_017003565.2 → XP_016859054.2  protein CREG2 isoform X1

      UniProtKB/TrEMBL
      Q580X0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      101804250..101846207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340948.1 → XP_054196923.1  protein CREG2 isoform X2

      UniProtKB/TrEMBL
      Q580X0

    2. XM_054340947.1 → XP_054196922.1  protein CREG2 isoform X1

      UniProtKB/TrEMBL
      Q580X0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IUH2.1 GenPept UniProtKB/Swiss-Prot:Q8IUH2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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