OSH2 oxysterol-binding protein related protein OSH2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: OSH2
Official Full Name: oxysterol-binding protein related protein OSH2
Primary source: SGD:S000002177
Locus tag: YDL019C
See related: AllianceGenome:SGD:S000002177; FungiDB:YDL019C; VEuPathDB:YDL019C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables lipid binding activity and sterol transfer activity. Involved in several processes, including ER to Golgi ceramide transport; maintenance of cell polarity; and piecemeal microautophagy of the nucleus. Acts upstream of or within reticulophagy. Located in several cellular components, including cellular bud neck; cortical endoplasmic reticulum; and nuclear envelope. Orthologous to human OSBP (oxysterol binding protein) and OSBP2 (oxysterol binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Coupled sterol synthesis and transport machineries at ER-endocytic contact sites.
Title: Coupled sterol synthesis and transport machineries at ER-endocytic contact sites.
there is no second site on PH(Osh2), which binds and indicates that PtdIns(4)P accumulates on the plasma membrane
Title: Multiple pools of phosphatidylinositol 4-phosphate detected using the pleckstrin homology domain of Osh2p.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables sterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables sterol transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol transfer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ER to Golgi ceramide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in maintenance of cell polarity	IEA Inferred from Electronic Annotation more info
involved_in maintenance of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IEA Inferred from Electronic Annotation more info
involved_in piecemeal microautophagy of the nucleus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within reticulophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sterol transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sterol transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cortical endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in perinuclear endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

NP_010265.1

Member of an oxysterol-binding protein family with seven members; in S. cerevisiae, family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane and at the nuclear envelope; regulated by sterol binding; OSH2 has a paralog, SWH1, that arose from the whole genome duplication

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