Arl3 ADP-ribosylation factor-like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arl3provided by MGI
Official Full Name: ADP-ribosylation factor-like 3provided by MGI
Primary source: MGI:MGI:1929699
See related: Ensembl:ENSMUSG00000025035 AllianceGenome:MGI:1929699
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including Golgi to plasma membrane transport; photoreceptor cell development; and protein localization to ciliary membrane. Acts upstream of or within intraciliary transport and smoothened signaling pathway. Located in axoneme; ciliary basal body; and ciliary transition zone. Is expressed in central nervous system; retina nuclear layer; and skin. Used to study autosomal recessive polycystic kidney disease and retinitis pigmentosa 2. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa 83. Orthologous to human ARL3 (ARF like GTPase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 63.8), CNS E18 (RPKM 46.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 38.94 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (46519548..46561621, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (46531109..46573182, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration.
Title: Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration.
In a mouse germline knockout of RP2, ARL3-GTP is abundant as its intrinsic GTPase activity is extremely low. High levels of ARL3-GTP impair binding and trafficking of cargo to the outer segment. This knockout is embryonically lethal causing a syndromic ciliopathy-like phenotype. The knockouts reveal binary functions of ARL3-GTP as a key molecule in late-stage photoreceptor ciliogenesis and cargo displacement. Review.
Title: Binary Function of ARL3-GTP Revealed by Gene Knockouts.
this study identifies ARL3 as a key player in prenylated protein trafficking in rod photoreceptor cells and establishes the potential role for ARL3 dysregulation in the pathogenesis of RP2-related forms of X-linked retinitis pigmentosa
Title: ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment.
Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).(
Title: Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).
The authors show that the ciliary G-protein Arl13B, mutated in Joubert syndrome, is the guanine nucleotide exchange factor for Arl3, and its function is conserved in evolution
Title: A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins.
ARL3 regulates protein trafficking and ciliogenesis in mouse photoreceptors.
Title: Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors.
Studies indicate that Arf-like proteins ARL2 and ARL3 are not substrates for N-myristoyl transferase.
Title: The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors.
A novel protein complex composed of Rabep1, GGA1 and Arl3 is responsible for the sorting and targeting of the polycystin 1 andpolycystin 2 to the cilium.
Title: Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism.
These findings uncovered the surprising functional relevance of GTP-bound Arl3 and LC8 for the unloading regulation of dynactin-bound cargo from dynein motor.
Title: Arl3 and LC8 regulate dissociation of dynactin from dynein.
Arl3 is a novel manchette-related protein with an important role in spermatogenesis.
Title: ADP-ribosylation factor-like 3, a manchette-associated protein, is essential for mouse spermiogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intraciliary transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in protein localization to ciliary membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary transition zone	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in photoreceptor connecting cilium	ISO Inferred from Sequence Orthology more info
located_in photoreceptor connecting cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info
located_in spindle microtubule	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 3

Names: ADP-ribosylation-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355233.1 → NP_001342162.1 ADP-ribosylation factor-like protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC156982

Consensus CDS

CCDS89412.1

UniProtKB/TrEMBL

A0A494BAJ6

Related

ENSMUSP00000158118.2, ENSMUST00000236255.2

Conserved Domains (1) summary

cd04155
Location:3 → 168

Arl3; Arf-like 3 (Arl3) GTPase
NM_019718.3 → NP_062692.1 ADP-ribosylation factor-like protein 3 isoform 1

See identical proteins and their annotated locations for NP_062692.1

Status: VALIDATED

Source sequence(s)

AC156982

Consensus CDS

CCDS38010.1

UniProtKB/Swiss-Prot

Q9WUL7

UniProtKB/TrEMBL

Q543P7

Related

ENSMUSP00000026009.9, ENSMUST00000026009.10

Conserved Domains (1) summary

cd04155
Location:3 → 176

Arl3; Arf-like 3 (Arl3) GTPase