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    C5ar1 complement C5a receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113959, updated on 9-Dec-2024

    Summary

    Official Symbol
    C5ar1provided by RGD
    Official Full Name
    complement C5a receptor 1provided by RGD
    Primary source
    RGD:70553
    See related
    EnsemblRapid:ENSRNOG00000074439 AllianceGenome:RGD:70553
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C5aR; C5r1; C5a-R
    Summary
    Enables complement component C5a binding activity and complement component C5a receptor activity. Involved in several processes, including animal organ regeneration; negative regulation of neuron apoptotic process; and response to lipopolysaccharide. Located in cell surface. Used to study adult respiratory distress syndrome; amyotrophic lateral sclerosis; neutropenia; obesity; and thrombosis. Biomarker of asthma and lung disease. Orthologous to human C5AR1 (complement C5a receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 44.4), Spleen (RPKM 33.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See C5ar1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (86077309..86088001, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (76948622..76959826, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (78186777..78195132, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 64-like Neighboring gene complement C5a receptor 2 Neighboring gene dynein light chain 1, cytoplasmic-like Neighboring gene InaF-motif containing 1 Neighboring gene coiled-coil domain containing 9 Neighboring gene Bcl-2 binding component 3

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables complement component C5a binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables complement component C5a receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables complement component C5a receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables complement component C5a receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables complement component C5a receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in astrocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell proliferation in hindbrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in complement component C5a signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in presynapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of tau-protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to peptidoglycan ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical part of cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    C5a anaphylatoxin chemotactic receptor 1
    Names
    complement component 5, receptor 1
    complement component 5a receptor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053619.2NP_446071.1  C5a anaphylatoxin chemotactic receptor 1

      See identical proteins and their annotated locations for NP_446071.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O09088, P97520
      UniProtKB/TrEMBL
      A6J8A2
      Conserved Domains (1) summary
      pfam00001
      Location:55302
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      86077309..86088001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105863.2XP_038961791.1  C5a anaphylatoxin chemotactic receptor 1 isoform X1

      Related
      ENSRNOP00000098952.1, ENSRNOT00000132351.1
      Conserved Domains (2) summary
      cd14964
      Location:1743
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:16290
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily