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    Ripk3 receptor-interacting serine-threonine kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246240, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ripk3provided by RGD
    Official Full Name
    receptor-interacting serine-threonine kinase 3provided by RGD
    Primary source
    RGD:628899
    See related
    EnsemblRapid:ENSRNOG00000020465 AllianceGenome:RGD:628899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rip3; Hcyp2
    Summary
    Predicted to enable identical protein binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including hematopoietic or lymphoid organ development; necroptotic process; and regulation of gene expression. Predicted to act upstream of or within with a positive effect on non-canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including positive regulation of intrinsic apoptotic signaling pathway; positive regulation of protein deacetylation; and positive regulation of reactive oxygen species metabolic process. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 101.3), Thymus (RPKM 69.4) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ripk3 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33253071..33262025, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29283153..29292107, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34470796..34479741, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene leukotriene B4 receptor Neighboring gene adenylate cyclase 4 Neighboring gene nuclear factor of activated T-cells 4 Neighboring gene NYN domain and retroviral integrase containing Neighboring gene cerebellin 3 precursor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell differentiation in thymus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in amyloid fibril formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amyloid fibril formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in execution phase of necroptosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in execution phase of necroptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lymph node development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lymph node development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in necroptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in necroptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in necroptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within_positive_effect non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of necroptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of necroptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in programmed necrotic cell death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of T cell mediated cytotoxicity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of activated T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of activation-induced cell death of T cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of activation-induced cell death of T cells ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of type II interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spleen development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spleen development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in thymus development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thymus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    receptor-interacting serine/threonine-protein kinase 3
    Names
    RIP-3
    RIP-like protein kinase 3
    homocysteine respondent protein HCYP2
    receptor-interacting protein 3
    NP_647558.2
    XP_038948911.1
    XP_063130035.1
    XP_063130036.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139342.2NP_647558.2  receptor-interacting serine/threonine-protein kinase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      B0BMV6, Q9Z2P5
      UniProtKB/TrEMBL
      A0A8I6A4Y2
      Related
      ENSRNOP00000027759.4, ENSRNOT00000027759.6
      Conserved Domains (2) summary
      pfam12721
      Location:408458
      RHIM; RIP homotypic interaction motif
      cl21453
      Location:28285
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33253071..33262025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273966.1XP_063130036.1  receptor-interacting serine/threonine-protein kinase 3 isoform X1

      UniProtKB/Swiss-Prot
      B0BMV6, Q9Z2P5
    2. XM_063273965.1XP_063130035.1  receptor-interacting serine/threonine-protein kinase 3 isoform X1

      UniProtKB/Swiss-Prot
      B0BMV6, Q9Z2P5
    3. XM_039092983.2XP_038948911.1  receptor-interacting serine/threonine-protein kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4Y2
      Conserved Domains (2) summary
      pfam12721
      Location:344394
      RHIM; RIP homotypic interaction motif
      cl21453
      Location:1217
      PKc_like; Protein Kinases, catalytic domain