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Nos3 nitric oxide synthase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24600, updated on 9-Dec-2024

Summary

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Official Symbol: Nos3provided by RGD
Official Full Name: nitric oxide synthase 3provided by RGD
Primary source: RGD:3186
See related: EnsemblRapid:ENSRNOG00000009348 AllianceGenome:RGD:3186
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: eNos
Summary: Enables several functions, including Hsp90 protein binding activity; beta-catenin binding activity; and calmodulin binding activity. Involved in several processes, including cellular response to cAMP; cellular response to magnesium ion; and cellular response to mechanical stimulus. Located in several cellular components, including apical part of cell; caveola; and sarcolemma. Used to study artery disease (multiple); irritable bowel syndrome; ischemia (multiple); liver disease (multiple); and retinal disease (multiple). Biomarker of several diseases, including artery disease (multiple); kidney failure (multiple); liver disease (multiple); lung disease (multiple); and overnutrition (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); eye disease (multiple); leukemia (multiple); reproductive organ cancer (multiple); and vasculitis (multiple). Orthologous to human NOS3 (nitric oxide synthase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 114.2), Spleen (RPKM 51.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Nos3 in Genome Data Viewer

Location:: 4q11

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (11686088..11706604, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (10793834..10814170, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (7321908..7342404, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca[2+] and NO signals.
Title: Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca(2+) and NO signals.
Immunoglobulin-Mediated Cardiac Protection From Ischemia/Reperfusion Injury in Diabetic Rats Is Associated With Endothelial Nitric Oxide Synthase/Glucose Transporter-4 Signaling Pathway.
Title: Immunoglobulin-Mediated Cardiac Protection From Ischemia/Reperfusion Injury in Diabetic Rats Is Associated With Endothelial Nitric Oxide Synthase/Glucose Transporter-4 Signaling Pathway.
Methylation of eNOS in the rat penile corpus cavernosum under different pathological states and its relationship with erectile function.
Title: Methylation of eNOS in the rat penile corpus cavernosum under different pathological states and its relationship with erectile function.
Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling.
Title: Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling.
Exploring the role of ATP-sensitive potassium channel, eNOS, and P-glycoprotein in mediating the hepatoprotective activity of nicorandil in methotrexate-induced liver injury in rats.
Title: Exploring the role of ATP-sensitive potassium channel, eNOS, and P-glycoprotein in mediating the hepatoprotective activity of nicorandil in methotrexate-induced liver injury in rats.
Food Restriction Augmented Alpha1-Adrenergic Mediated Contraction in Mesenteric Arteries.
Title: Food Restriction Augmented Alpha1-Adrenergic Mediated Contraction in Mesenteric Arteries.
Hypoglycaemia aggravates impaired endothelial-dependent vasodilation in diabetes by suppressing endothelial nitric oxide synthase activity and stimulating inducible nitric oxide synthase expression.
Title: Hypoglycaemia aggravates impaired endothelial-dependent vasodilation in diabetes by suppressing endothelial nitric oxide synthase activity and stimulating inducible nitric oxide synthase expression.
beta-PIX cooperates with GIT1 to regulate endothelial nitric oxide synthase in sinusoidal endothelial cells.
Title: β-PIX cooperates with GIT1 to regulate endothelial nitric oxide synthase in sinusoidal endothelial cells.
An activatable fluorescent probe for imaging endogenous nitric oxide via the eNOS enzymatic pathway.
Title: An activatable fluorescent probe for imaging endogenous nitric oxide via the eNOS enzymatic pathway.
Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics.
Title: Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics.

Submit: New GeneRIF Correction See all GeneRIFs (373)

General gene information

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Markers

Nos3 (e-PCR), detects polymorphism
- UniSTS:546896

d4mgh28 (e-PCR)
- UniSTS:120435

UniSTS:166287 (e-PCR)
- UniSTS:166287

Nos3 (e-PCR), detects polymorphism
- UniSTS:166287

Nos3 (e-PCR), detects polymorphism
- UniSTS:144043

PMC155039P1 (e-PCR)
- UniSTS:271323

RH138584 (e-PCR)
- UniSTS:220671

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FMN binding	IBA Inferred from Biological aspect of Ancestor more info
enables FMN binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin monomer binding	IEA Inferred from Electronic Annotation more info
enables actin monomer binding	ISO Inferred from Sequence Orthology more info
enables arginine binding	IEA Inferred from Electronic Annotation more info
enables arginine binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitric-oxide synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nitric-oxide synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables nitric-oxide synthase activity	IEA Inferred from Electronic Annotation more info
enables nitric-oxide synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables tetrahydrobiopterin binding	IEA Inferred from Electronic Annotation more info
enables tetrahydrobiopterin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in aortic valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in arginine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in arginine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in blood vessel diameter maintenance	ISO Inferred from Sequence Orthology more info
involved_in blood vessel remodeling	IEA Inferred from Electronic Annotation more info
involved_in blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in bone development	IEP Inferred from Expression Pattern more info	PubMed
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to high density lipoprotein particle stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to low-density lipoprotein particle stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to magnesium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to rotenone	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in endocardial cushion morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in endocardial cushion morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in homeostasis of number of cells within a tissue	IEA Inferred from Electronic Annotation more info
involved_in homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lung development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of biomineral tissue development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of hydrolase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle hyperplasia	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of muscle hyperplasia	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in nitric oxide metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in ovulation from ovarian follicle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ovulation from ovarian follicle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of guanylate cyclase activity	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in pulmonary valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of nervous system process	IEA Inferred from Electronic Annotation more info
involved_in regulation of nervous system process	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure by endothelin	IEA Inferred from Electronic Annotation more info
involved_in regulation of systemic arterial blood pressure by endothelin	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction by chemical signal	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of the force of heart contraction by chemical signal	ISO Inferred from Sequence Orthology more info
involved_in removal of superoxide radicals	IEA Inferred from Electronic Annotation more info
involved_in removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
involved_in response to L-arginine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to carbohydrate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to erythropoietin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fluid shear stress	IEA Inferred from Electronic Annotation more info
involved_in response to fluid shear stress	ISO Inferred from Sequence Orthology more info
involved_in response to fructose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ketone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to magnetism	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mercury ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ultrasound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in retina development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
involved_in smooth muscle hyperplasia	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle hyperplasia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasodilation	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nitric oxide synthase 3

Names: EC-NOS; NOS type III; NOSIII; cNOS; constitutive NOS; endothelial NOS; endothelial nitric oxide synthase 3; nitric oxide synthase 3, endothelial cell; nitric oxide synthase, endothelial

NP_068610.1

EC 1.14.13.39

XP_006235934.1

EC 1.14.13.39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021838.2 → NP_068610.1 nitric oxide synthase 3

See identical proteins and their annotated locations for NP_068610.1

Status: PROVISIONAL

Source sequence(s)

AB176831

UniProtKB/TrEMBL

A0A8I6A2Y1

Related

ENSRNOP00000013058.4, ENSRNOT00000013058.6

Conserved Domains (5) summary

COG0369
Location:511 → 1158

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

cd00795
Location:67 → 479

NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...

pfam00258
Location:521 → 697

Flavodoxin_1; Flavodoxin

pfam01698
Location:30 → 61

FLO_LFY; Floricaula / Leafy protein

cl06868
Location:761 → 1163

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

11686088..11706604 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235872.3 → XP_006235934.1 nitric oxide synthase 3 isoform X1

UniProtKB/TrEMBL

A0A8I6A2Y1

Related

ENSRNOP00000086104.2, ENSRNOT00000118104.2

Conserved Domains (4) summary

COG0369
Location:461 → 1108

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

cd00795
Location:17 → 429

NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...

pfam00258
Location:471 → 647

Flavodoxin_1; Flavodoxin

cl06868
Location:711 → 1113

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...