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    slc-25A10 Mitochondrial dicarboxylate carrier [ Caenorhabditis elegans ]

    Gene ID: 180940, updated on 9-Dec-2024

    Summary

    Official Symbol
    slc-25A10
    Official Full Name
    Mitochondrial dicarboxylate carrier
    Primary source
    WormBase:WBGene00019656
    Locus tag
    CELE_K11G12.5
    See related
    AllianceGenome:WB:WBGene00019656
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable C4-dicarboxylate transmembrane transporter activity; antiporter activity; and sulfur compound transmembrane transporter activity. Predicted to be involved in C4-dicarboxylate transport; inorganic anion transmembrane transport; and thiosulfate transport. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 19. Orthologous to human SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See slc-25A10 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (6723743..6725668, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Zinc metalloproteinase nas-11 Neighboring gene NRAMP-like transporter smf-2 Neighboring gene NRAMP-like transporter smf-1 Neighboring gene Lipase maturation factor Neighboring gene Glycosyl hydrolase family 63 C-terminal domain-containing protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dicarboxylic acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables malate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxaloacetate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables succinate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thiosulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in malate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oxaloacetate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oxaloacetate(2-) transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in succinate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thiosulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Mitochondrial dicarboxylate carrier
    NP_509133.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6723743..6725668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076732.6NP_509133.1  Mitochondrial dicarboxylate carrier [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509133.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EE96
      Conserved Domains (2) summary
      PTZ00169
      Location:3279
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:1591
      Mito_carr; Mitochondrial carrier protein