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    Gys2 glycogen synthase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25623, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gys2provided by RGD
    Official Full Name
    glycogen synthase 2provided by RGD
    Primary source
    RGD:2773
    See related
    EnsemblRapid:ENSRNOG00000059753 AllianceGenome:RGD:2773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GLYSN
    Summary
    Enables D-glucose binding activity and alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity. Involved in glycogen biosynthetic process and response to glucose. Located in cortical actin cytoskeleton and cytosol. Human ortholog(s) of this gene implicated in glycogen storage disease. Orthologous to human GYS2 (glycogen synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 213.1), Thymus (RPKM 72.0) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gys2 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (177096063..177137236, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (175365054..175406228, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (176638632..176679805, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene golgi transport 1B Neighboring gene spexin hormone Neighboring gene lactate dehydrogenase B Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycogen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycogen metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glycogen [starch] synthase, liver
    Names
    Glycogen synthase 2 (liver)
    NP_037221.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013089.2NP_037221.2  glycogen [starch] synthase, liver

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P17625, Q99MF8
      UniProtKB/TrEMBL
      D4A5K9
      Related
      ENSRNOP00000074743.1, ENSRNOT00000090122.3
      Conserved Domains (2) summary
      cd03793
      Location:27615
      GT1_Glycogen_synthase_GSY2_like; Glycogen synthase, which is most closely related to the GT1 family of glycosyltransferases, catalyzes the transfer of a glucose molecule from UDP-glucose to a terminal branch of a glycogen molecule, a rate-limit step of glycogen biosynthesis. GSY2, the ...
      pfam05693
      Location:32660
      Glycogen_syn; Glycogen synthase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      177096063..177137236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)