Pmpca peptidase, mitochondrial processing subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pmpcaprovided by RGD
Official Full Name: peptidase, mitochondrial processing subunit alphaprovided by RGD
Primary source: RGD:727897
See related: EnsemblRapid:ENSRNOG00000026775 AllianceGenome:RGD:727897
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables endopeptidase activity. Contributes to metallopeptidase activity. Involved in protein processing. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 2. Orthologous to human PMPCA (peptidase, mitochondrial processing subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 263.8), Muscle (RPKM 245.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (29605823..29614936)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (9207731..9216846)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (3834262..3842061)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
contributes_to metallopeptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing involved in protein targeting to mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing involved in protein targeting to mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in protein processing involved in protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in protein processing involved in protein targeting to mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	TAS Traceable Author Statement more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial-processing peptidase subunit alpha

Names: P-55; alpha-MPP; inactive zinc metalloprotease alpha; mitochondrial processing peptidase alpha subunit, mitochondrial; peptidase (mitochondrial processing) alpha; peptidase, mitochondrial processing alpha subunit

NP_001003673.1

EC 3.4.24.64

XP_038960652.1

EC 3.4.24.64

XP_063139541.1

EC 3.4.24.64

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003673.1 → NP_001003673.1 mitochondrial-processing peptidase subunit alpha

See identical proteins and their annotated locations for NP_001003673.1

Status: VALIDATED

Source sequence(s)

BC079004, CB806391

UniProtKB/TrEMBL

A6JTE5, F1M964, F7F3I1, Q68FX8

Related

ENSRNOP00000037642.2, ENSRNOT00000031607.6

Conserved Domains (1) summary

COG0612
Location:64 → 503

PqqL; Predicted Zn-dependent peptidase [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

29605823..29614936

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104724.2 → XP_038960652.1 mitochondrial-processing peptidase subunit alpha isoform X1

UniProtKB/TrEMBL

A0A8I6AB79, F1M964

Related

ENSRNOP00000090125.1, ENSRNOT00000105584.2

Conserved Domains (1) summary

COG0612
Location:78 → 517

PqqL; Predicted Zn-dependent peptidase [General function prediction only]
XM_063283471.1 → XP_063139541.1 mitochondrial-processing peptidase subunit alpha isoform X2