Ak1 adenylate kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ak1provided by RGD
Full Name: adenylate kinase 1provided by RGD
Primary source: RGD:2076
See related: EnsemblRapid:ENSRNOG00000049056 AllianceGenome:RGD:2076
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ak 1
Summary: Enables adenylate kinase activity. Contributes to phosphotransferase activity, phosphate group as acceptor. Involved in several processes, including inosine biosynthetic process; nervous system development; and purine ribonucleotide metabolic process. Located in perinuclear region of cytoplasm and sarcomere. Biomarker of middle cerebral artery infarction; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 1320.1), Heart (RPKM 466.8) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (36310113..36320760)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (15912431..15923045)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (11652143..11659135)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of AMP kinase ameliorates kidney vascular dysfunction, oxidative stress and inflammation in rodent models of obesity.
Title: Activation of AMP kinase ameliorates kidney vascular dysfunction, oxidative stress and inflammation in rodent models of obesity.
Data indicate that the beta-alanine administration was able to inhibit the enzyme pyruvate kinase, cytosolic creatine kinase, and adenylate kinase activities in cerebral cortex, and increase in cerebellum.
Title: Effects of β-alanine administration on selected parameters of oxidative stress and phosphoryltransfer network in cerebral cortex and cerebellum of rats.
it is the activation of AMPK that plays a crucial role in mediating autophagic cell death induced by 5-aminolevulinic acid (ALA)-mediated photodynamic therapy
Title: 5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase.
Adenylate kinase activity was found diminished in the brain cortex of rats loaded with cystine dimethylester and co-administration of cysteamine prevented the diminution of the enzyme activity.
Title: Cysteamine prevents inhibition of adenylate kinase caused by cystine in rat brain cortex.
adenylate kinase (AK) was increased in senescent muscle fibres.
Title: Opposite pathobiochemical fate of pyruvate kinase and adenylate kinase in aged rat skeletal muscle as revealed by proteomic DIGE analysis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI073285 (e-PCR)
- UniSTS:245460

NoName (e-PCR)
- UniSTS:238051

RH137043 (e-PCR)
- UniSTS:219132

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables (deoxy)adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate kinase activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to phosphotransferase activity, phosphate group as acceptor	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ADP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ADP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in AMP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in AMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in adenine metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in inosine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in muscle organ development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in nucleoside monophosphate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in nucleoside triphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in olfactory bulb development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of D-glucose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron maturation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in outer dense fiber	IEA Inferred from Electronic Annotation more info
located_in outer dense fiber	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenylate kinase isoenzyme 1

Names: ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; adenylate kinase isoenzyme 1-like; adenylate monophosphate kinase; myokinase

NP_077325.2

EC 2.7.4.3

EC 2.7.4.4

EC 2.7.4.6

XP_038960159.1

EC 2.7.4.3

EC 2.7.4.4

EC 2.7.4.6

XP_038960160.1

EC 2.7.4.3

EC 2.7.4.4

EC 2.7.4.6

XP_038960161.1

EC 2.7.4.3

EC 2.7.4.4

EC 2.7.4.6

XP_038960162.1

EC 2.7.4.3

EC 2.7.4.4

EC 2.7.4.6

XP_038960163.1

EC 2.7.4.3

EC 2.7.4.4

EC 2.7.4.6

XP_063139143.1

EC 2.7.4.3

EC 2.7.4.4

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024349.4 → NP_077325.2 adenylate kinase isoenzyme 1

See identical proteins and their annotated locations for NP_077325.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P39069, Q5EBC5, Q9JJN3

UniProtKB/TrEMBL

A6JU72, A6JU73

Related

ENSRNOP00000067175.4, ENSRNOT00000073840.4

Conserved Domains (1) summary

TIGR01360
Location:6 → 193

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

36310113..36320760

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104232.2 → XP_038960160.1 adenylate kinase isoenzyme 1 isoform X2

UniProtKB/Swiss-Prot

P39069, Q5EBC5, Q9JJN3

UniProtKB/TrEMBL

A6JU72, A6JU73

Conserved Domains (1) summary

TIGR01360
Location:6 → 193

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
XM_039104234.2 → XP_038960162.1 adenylate kinase isoenzyme 1 isoform X2

UniProtKB/Swiss-Prot

P39069, Q5EBC5, Q9JJN3

UniProtKB/TrEMBL

A6JU72, A6JU73

Conserved Domains (1) summary

TIGR01360
Location:6 → 193

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
XM_039104233.2 → XP_038960161.1 adenylate kinase isoenzyme 1 isoform X2

UniProtKB/Swiss-Prot

P39069, Q5EBC5, Q9JJN3

UniProtKB/TrEMBL

A6JU72, A6JU73

Related

ENSRNOP00000074303.2, ENSRNOT00000091048.3

Conserved Domains (1) summary

TIGR01360
Location:6 → 193

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
XM_063283073.1 → XP_063139143.1 adenylate kinase isoenzyme 1 isoform X2

UniProtKB/Swiss-Prot

P39069, Q5EBC5, Q9JJN3

UniProtKB/TrEMBL

A6JU73
XM_039104235.2 → XP_038960163.1 adenylate kinase isoenzyme 1 isoform X2

UniProtKB/Swiss-Prot

P39069, Q5EBC5, Q9JJN3

UniProtKB/TrEMBL

A6JU72, A6JU73

Conserved Domains (1) summary

TIGR01360
Location:6 → 193

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
XM_039104231.2 → XP_038960159.1 adenylate kinase isoenzyme 1 isoform X1

UniProtKB/TrEMBL

A6JU72, A6JU74, M0RC66

Related

ENSRNOP00000109041.1, ENSRNOT00000152600.1

Conserved Domains (1) summary

TIGR01360
Location:22 → 209

aden_kin_iso1; adenylate kinase, isozyme 1 subfamily