sup-46 RRM domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sup-46
Official Full Name: RRM domain-containing protein
Primary source: WormBase:WBGene00045383
Locus tag: CELE_C25A1.4
See related: AllianceGenome:WB:WBGene00045383
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in germ cell and somatic cell. Orthologous to human HNRNPM (heterogeneous nuclear ribonucleoprotein M) and MYEF2 (myelin expression factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sup-46 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (10169639..10172603, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors identified SUP-46 as an HNRNPM family RNA-binding protein, and uncovered a highly novel role for SUP-46 in preventing paternally-mediated progressive germline mortality following mating.
Title: C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C25A1.4 (e-PCR)
- UniSTS:306743

STS1-3 (e-PCR)
- UniSTS:241756

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RRM domain-containing protein

NP_492677.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10169639..10172603 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060276.6 → NP_492677.1 RRM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492677.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XVS2

Conserved Domains (4) summary

COG0724
Location:47 → 123

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd00590
Location:387 → 452

RRM_SF; RNA recognition motif (RRM) superfamily

cd12386
Location:190 → 263

RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins

cl17169
Location:47 → 120

RRM_SF; RNA recognition motif (RRM) superfamily