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    Hrk harakiri, BCL2 interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117271, updated on 27-Nov-2024

    Summary

    Official Symbol
    Hrkprovided by RGD
    Official Full Name
    harakiri, BCL2 interacting proteinprovided by RGD
    Primary source
    RGD:70549
    See related
    EnsemblRapid:ENSRNOG00000079458 AllianceGenome:RGD:70549
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dp5; Bid3
    Summary
    Involved in cellular response to potassium ion starvation and positive regulation of neuron apoptotic process. Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to human HRK (harakiri, BCL2 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: NM_057130.4 is based on transcript and protein alignment data, and may not be a true representation of the structure of GeneID 117271 due to the incomplete nature of the assembly in this region of the genome. [10 Oct 2014]
    Expression
    Biased expression in Brain (RPKM 47.4) and Adrenal (RPKM 3.3) See more
    Orthologs
    NEW
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    Genomic context

    See Hrk in Genome Data Viewer
    Location:
    12q16
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (44048402..44070561, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (38387484..38409652, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (44008879..44029211, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene SREBF pathway regulator in golgi 1 Neighboring gene ring finger protein, transmembrane 2 Neighboring gene uncharacterized LOC102553921 Neighboring gene U6 spliceosomal RNA Neighboring gene F-box and WD repeat domain containing 8 Neighboring gene uncharacterized LOC134481299 Neighboring gene tescalcin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    activator of apoptosis harakiri
    Names
    BH3 interacting (with BCL2 family) domain, apoptosis agonist
    BH3 interacting domain 3
    BH3-interacting domain-containing protein 3
    harakiri, BCL2 interacting protein (contains only BH3 domain)
    neuronal death protein DP5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057130.5NP_476471.1  activator of apoptosis harakiri

      See identical proteins and their annotated locations for NP_476471.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      P62817
      Related
      ENSRNOP00000106855.1, ENSRNOT00000122802.1
      Conserved Domains (1) summary
      pfam15196
      Location:192
      Harakiri; Activator of apoptosis harakiri

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      44048402..44070561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)