Ivd isovaleryl-CoA dehydrogenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ivdprovided by RGD
Official Full Name: isovaleryl-CoA dehydrogenaseprovided by RGD
Primary source: RGD:2936
See related: EnsemblRapid:ENSRNOG00000009421 AllianceGenome:RGD:2936
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables 3-methylbutanoyl-CoA dehydrogenase activity and identical protein binding activity. Involved in L-leucine catabolic process. Located in mitochondrial matrix and mitochondrial membrane. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and isovaleric acidemia. Orthologous to human IVD (isovaleryl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 893.2), Adrenal (RPKM 714.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (126305584..126326016)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (105851710..105872144)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (110669355..110689789)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Isovaleryl-CoA dehydrogenase has relatively broader substrate specificity than those of the other two enzymes in accommodating various substrate analogs.
Title: Comparative studies of Acyl-CoA dehydrogenases for monomethyl branched chain substrates in amino acid metabolism.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI463340 (e-PCR)
- UniSTS:159003

D3Arb26 (e-PCR)
- UniSTS:239516

AU048627 (e-PCR)
- UniSTS:145077

D3Wox27 (e-PCR)
- UniSTS:119266

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-methylbutanoyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-methylbutanoyl-CoA dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-methylbutanoyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables short-chain fatty acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-leucine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-leucine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in L-leucine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-leucine metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in branched-chain amino acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in carboxylic acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IC Inferred by Curator more info	PubMed
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: isovaleryl-CoA dehydrogenase, mitochondrial

Names: butyryl-CoA dehydrogenase; isovaleryl coenzyme A dehydrogenase

NP_036724.1

EC 1.3.8.1

EC 1.3.8.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012592.2 → NP_036724.1 isovaleryl-CoA dehydrogenase, mitochondrial precursor

See identical proteins and their annotated locations for NP_036724.1

Status: PROVISIONAL

Source sequence(s)

BC088401

UniProtKB/Swiss-Prot

P12007

UniProtKB/TrEMBL

A0A8I6A3D0, A6HPD3

Related

ENSRNOP00000013829.4, ENSRNOT00000013829.7

Conserved Domains (2) summary

cd01156
Location:42 → 421

IVD; Isovaleryl-CoA dehydrogenase

PLN02519
Location:43 → 417

PLN02519; isovaleryl-CoA dehydrogenase