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    Hrh2 histamine receptor H 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25461, updated on 27-Nov-2024

    Summary

    Official Symbol
    Hrh2provided by RGD
    Official Full Name
    histamine receptor H 2provided by RGD
    Primary source
    RGD:2831
    See related
    EnsemblRapid:ENSRNOG00000018260 AllianceGenome:RGD:2831
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    H2R; HH2R
    Summary
    Enables heterocyclic compound binding activity and histamine receptor activity. Involved in cellular response to histamine and negative regulation of arachidonate secretion. Predicted to be located in synapse. Predicted to be active in dendrite and plasma membrane. Biomarker of transient cerebral ischemia. Orthologous to human HRH2 (histamine receptor H2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 17.7), Spleen (RPKM 8.2) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Hrh2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (10371083..10412979, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (10366004..10407791, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (10912959..10931389, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097924 Neighboring gene long non-coding RNA 012 Neighboring gene uncharacterized LOC134482680 Neighboring gene complexin 2 Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 1 Neighboring gene ribosomal protein L35A like 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heterocyclic compound binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histamine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histamine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histamine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to histamine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within digestive tract development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gastric acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within gastric acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gastrin-induced gastric acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gland development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within histamine-induced gastric acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of arachidonate secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    histamine H2 receptor
    Names
    gastric receptor I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413011.1NP_001399940.1  histamine H2 receptor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      10371083..10412979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276079.1XP_063132149.1  histamine H2 receptor isoform X1

      Related
      ENSRNOP00000111031.1, ENSRNOT00000141382.1

    RNA

    1. XR_596619.4 RNA Sequence

    2. XR_005495238.2 RNA Sequence