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    Il1rl2 interleukin 1 receptor-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171106, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il1rl2provided by RGD
    Official Full Name
    interleukin 1 receptor-like 2provided by RGD
    Primary source
    RGD:621782
    See related
    EnsemblRapid:ENSRNOG00000014683 AllianceGenome:RGD:621782
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NAD+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; and interleukin-1 receptor activity. Predicted to be involved in cell surface receptor signaling pathway and regulation of inflammatory response. Predicted to act upstream of or within positive regulation of T cell differentiation and positive regulation of interleukin-6 production. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Orthologous to human IL1RL2 (interleukin 1 receptor like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 10.1), Lung (RPKM 9.0) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il1rl2 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (50087271..50134225)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (42591658..42639351)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (47044870..47093679)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene H3.3 histone A like 3 Neighboring gene interleukin 1 receptor type 1 Neighboring gene interleukin 1 receptor-like 1 Neighboring gene interleukin 18 receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass. Luo C, et al. Med Sci Monit, 2020 Feb 12. PMID 32048631, Free PMC Article
    2. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2). Lovenberg TW, et al. J Neuroimmunol, 1996 Nov. PMID 8898719
    3. Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. Tortola L, et al. J Clin Invest, 2012 Nov. PMID 23064362, Free PMC Article
    4. IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells. Vigne S, et al. Blood, 2012 Oct 25. PMID 22968459
    5. IL-36R ligands are potent regulators of dendritic and T cells. Vigne S, et al. Blood, 2011 Nov 24. PMID 21860022

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass.
      Title: Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-1 receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-1 receptor-like 2
    Names
    IL-1Rrp2
    IL-36 receptor
    IL1R-rp2
    interleukin-1 receptor-related protein 2
    NP_598259.2
    XP_017451748.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133575.2 → NP_598259.2  interleukin-1 receptor-like 2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q62929
      UniProtKB/TrEMBL
      A6INN3, G3V7W4
      Related
      ENSRNOP00000110127.1, ENSRNOT00000135930.1
      Conserved Domains (3) summary
      pfam01582
      Location:389 → 539
      TIR; TIR domain
      cd00096
      Location:31 → 35
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:26 → 115
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      50087271..50134225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596259.3 → XP_017451748.1  interleukin-1 receptor-like 2 isoform X1

      UniProtKB/Swiss-Prot
      Q62929
      UniProtKB/TrEMBL
      A6INN3, G3V7W4
      Related
      ENSRNOP00000098736.1, ENSRNOT00000137233.1
      Conserved Domains (3) summary
      pfam01582
      Location:389 → 539
      TIR; TIR domain
      cd00096
      Location:31 → 35
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:26 → 115
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62929.1 GenPept UniProtKB/Swiss-Prot:Q62929

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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