DXO1 Dxo1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: DXO1
Official Full Name: Dxo1p
Primary source: SGD:S000002778
Locus tag: YDR370C
See related: AllianceGenome:SGD:S000002778; FungiDB:YDR370C; VEuPathDB:YDR370C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 5'-3' RNA exonuclease activity. Involved in maturation of LSU-rRNA. Acts upstream of or within NAD-cap decapping and nuclear-transcribed mRNA catabolic process, no-go decay. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 5'-3' RNA exonuclease activity	IGI Inferred from Genetic Interaction more info	PubMed
enables 5'-3' RNA exonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables mRNA 5'-diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD-cap decapping	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within NAD-cap decapping	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within NAD-cap decapping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of LSU-rRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, no-go decay	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

NP_010658.3

Cytoplasmic 5' exoribonuclease; transcriptomics wide distributive exonuclease; involved in cytoplasmic mRNA degradation, turnover of tRNA introns and processing of spliceosomal introns; required for the final 5'-end processing of 25S rRNA; minor contributor to No-Go Decay and the unfolded protein response; decapping protein involved in surveillance and removal of non-canonical nicotinamide adenine dinucleotide (NAD) capped nuclear mRNAs (NAD-RNAs); sequence similarity to Rai1p