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    Sh3kbp1 SH3 domain-containing kinase-binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84357, updated on 3-Dec-2024

    Summary

    Official Symbol
    Sh3kbp1provided by RGD
    Official Full Name
    SH3 domain-containing kinase-binding protein 1provided by RGD
    Primary source
    RGD:620904
    See related
    EnsemblRapid:ENSRNOG00000004322 AllianceGenome:RGD:620904
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Seta; CIN85
    Summary
    Enables ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including actin filament organization; positive regulation of B cell activation; and regulation of cell shape. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Human ortholog(s) of this gene implicated in immunodeficiency 61. Orthologous to human SH3KBP1 (SH3 domain containing kinase binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 509.1), Thymus (RPKM 268.2) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sh3kbp1 in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (38686530..39031658, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (34877862..35223013, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (37790004..38196365, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene pyruvate dehydrogenase E1 subunit alpha 1 Neighboring gene ubiquitin-like 4A, pseudogene Neighboring gene BCLAF1 and THRAP3 family member 3 Neighboring gene ribosomal protein S9, pseudogene 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of B cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of B cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    SH3 domain-containing kinase-binding protein 1
    Names
    SH3 domain-containing adapter protein
    SH3-containing, expressed in tumorigenic astrocytes
    SH3-domain kinase binding protein 1
    regulator of ubiquitous kinase
    ruk

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053360.3NP_445812.1  SH3 domain-containing kinase-binding protein 1

      See identical proteins and their annotated locations for NP_445812.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6IPM0, Q6IRL5
      Related
      ENSRNOP00000093532.2, ENSRNOT00000095370.2
      Conserved Domains (3) summary
      cd12052
      Location:355
      SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
      cd12055
      Location:102154
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:271326
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      38686530..39031658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100102.2XP_038956030.1  SH3 domain-containing kinase-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A6IPM1
      Related
      ENSRNOP00000107405.1, ENSRNOT00000142445.1
      Conserved Domains (3) summary
      cd12052
      Location:355
      SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
      cd12055
      Location:102154
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:315370
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    2. XM_039100103.2XP_038956031.1  SH3 domain-containing kinase-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A6IPM1
      Conserved Domains (3) summary
      cd12052
      Location:355
      SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
      cd12055
      Location:102154
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:296351
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    3. XM_006256931.3XP_006256993.1  SH3 domain-containing kinase-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006256993.1

      UniProtKB/Swiss-Prot
      Q925Q9, Q925R0, Q925R1, Q925R2, Q925R3, Q9JKQ0, Q9JKQ1, Q9JLU9
      UniProtKB/TrEMBL
      A6IPL9, A6IPM1
      Related
      ENSRNOP00000006741.7, ENSRNOT00000006741.9
      Conserved Domains (3) summary
      cd12052
      Location:355
      SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
      cd12055
      Location:102154
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:315370
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    4. XM_039100100.2XP_038956028.1  SH3 domain-containing kinase-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A6IPM1, M0RBZ7
      Related
      ENSRNOP00000067100.3, ENSRNOT00000074898.4
      Conserved Domains (3) summary
      cd12052
      Location:355
      SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
      cd12055
      Location:102154
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:296351
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    5. XM_039100101.2XP_038956029.1  SH3 domain-containing kinase-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0H2UHD8, A6IPM0
      Related
      ENSRNOP00000006438.5, ENSRNOT00000006438.8
      Conserved Domains (3) summary
      cd12052
      Location:355
      SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
      cd12055
      Location:102154
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:290345
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    6. XM_039100104.2XP_038956032.1  SH3 domain-containing kinase-binding protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I6AJT1, A6IPM0
      Conserved Domains (3) summary
      cd12052
      Location:355
      SH3_CIN85_1; First Src Homology 3 domain (SH3A) of Cbl-interacting protein of 85 kDa
      cd12055
      Location:102154
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:271326
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    7. XM_063280333.1XP_063136403.1  SH3 domain-containing kinase-binding protein 1 isoform X10

      UniProtKB/TrEMBL
      A6IPM2
    8. XM_063280332.1XP_063136402.1  SH3 domain-containing kinase-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A6IPM2
    9. XM_006256924.5XP_006256986.3  SH3 domain-containing kinase-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A6IPM1
      Conserved Domains (2) summary
      cd12055
      Location:65117
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:278333
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    10. XM_006256929.5XP_006256991.3  SH3 domain-containing kinase-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A8U3, A6IPM2
      Related
      ENSRNOP00000089759.1, ENSRNOT00000113102.2
      Conserved Domains (2) summary
      cd12055
      Location:65117
      SH3_CIN85_2; Second Src Homology 3 domain (SH3B) of Cbl-interacting protein of 85 kDa
      cd12057
      Location:234289
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    11. XM_006256930.5XP_006256992.1  SH3 domain-containing kinase-binding protein 1 isoform X11

      See identical proteins and their annotated locations for XP_006256992.1

      UniProtKB/TrEMBL
      A6IPM3, A6IPM4
      Related
      ENSRNOP00000083463.1, ENSRNOT00000096669.2
      Conserved Domains (1) summary
      cd12057
      Location:3388
      SH3_CIN85_3; Third Src Homology 3 domain (SH3C) of Cbl-interacting protein of 85 kDa
    12. XM_063280334.1XP_063136404.1  SH3 domain-containing kinase-binding protein 1 isoform X12

      UniProtKB/TrEMBL
      A6IPM4
    13. XM_063280335.1XP_063136405.1  SH3 domain-containing kinase-binding protein 1 isoform X14

    14. XM_008773199.4XP_008771421.1  SH3 domain-containing kinase-binding protein 1 isoform X13

    15. XM_063280336.1XP_063136406.1  SH3 domain-containing kinase-binding protein 1 isoform X15

      UniProtKB/TrEMBL
      A6IPM6
    16. XM_008773200.4XP_008771422.1  SH3 domain-containing kinase-binding protein 1 isoform X15

      See identical proteins and their annotated locations for XP_008771422.1

      UniProtKB/TrEMBL
      A6IPM6